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BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal

Authors:	Annemarie Heberlein Marc Muschler Julia Wilhelm Helge Frieling Bernd Lenz Michael Gröschl Johannes Kornhuber Stefan Bleich Thomas Hillemacher

Institution:	1. Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany;2. Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany;3. Department of Pediatrics, University Hospital Erlangen, Germany

Abstract:	Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we investigated alterations in BDNF (81 male patients) and GDNF serum levels (52 male patients) in alcohol-dependent patients during alcohol withdrawal (day 1, 7 and 14) in comparison to healthy controls (41 male controls).

Keywords:	AAT aspartate aminotransferase ALAT alanine aminotransferase AUDIT-C Alcohol Use Disorder Identification Test&ndash Alcohol Consumption Questions BAC Breath Alcohol Concentration BDI Beck's Depression Inventory BDNF Brain-derived neurotrophic factor BMI body mass index CIWA-Ar Clinical Institute Withdrawal Assessment for Alcohol DI daily intake of alcohol in grams DSM-IV Diagnostic and Statistical Manual of Mental Disorders GDNF Glial cell-line derived neurotrophic factor GGT gamma glutamyl transferase ICD-10 International Classification of Diseases LC leukocyte count N A not available OCDS Obsessive and Compulsive Drinking Scale SD standard deviation SESA Severity Scale of Alcohol Dependence STAI-I State Anxiety State and Trait Anxiety Inventory STAI-II Trait Anxiety State and Trait Anxiety Inventory TC thrombocyte count YD years of drinking
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