首页 | 本学科首页   官方微博 | 高级检索  
检索        


Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
Authors:Tsutomu Takahashi  Stephen J Wood  Bridget Soulsby  Ryoichiro Tanino  Michael TH Wong  Patrick D McGorry  Michio Suzuki  Dennis Velakoulis  Christos Pantelis
Institution:1. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia;2. Department of Neuropsychiatry, University of Toyama, Toyama, Japan;3. Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan;4. ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Victoria, Australia;5. Department of Psychological Medicine, Monash University, Clayton, Victoria, Australia
Abstract:Volume reductions of the insular cortex have been described in schizophrenia, but it remains unclear whether other psychotic disorders such as affective psychosis also exhibit insular cortex abnormalities. In this study, we used magnetic resonance imaging to investigate the gray matter volume of the anterior (short) and posterior (long) insular cortices in 162 first-episode patients with various psychotic disorders (46 schizophrenia, 57 schizophreniform disorder, 34 affective psychosis, and 25 other psychoses) and 62 age- and gender-matched healthy comparison subjects. Patients with schizophrenia showed bilateral volume reduction of the anterior and posterior insular cortices compared with controls, but the remaining first-episode psychosis subgroups had normal insular volumes. The volumes of these insular subregions were significantly smaller in schizophrenia patients than in patients with schizophreniform disorder or affective psychoses. There was no association between the insular cortex volume and daily dosage or type of antipsychotic medication in any patient group. These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia.
Keywords:ANCOVA  analysis of covariance  ANOVA  analysis of variance  DSM-III-R  Diagnostic and Statistical Manual of Mental Disorders Revised Third Edition  DSM-IV  Diagnostic and Statistical Manual of Mental Disorders Fourth Edition  EPPIC  Early Psychosis Prevention and Intervention Centre  FEP  first-episode psychosis  ICC  intraclass correlation coefficient  ICV  intracranial volume  MRI  magnetic resonance imaging  RPMIP  Royal Park Multidiagnostic Instrument for Psychosis  ROI  region of interest  SCID  Structured Clinical Interview for DSM-III-R  VBM  voxel based morphometry
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号