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Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder
Authors:Lee Byeong-Taek  Seok Jeong-Ho  Lee Boung-Chul  Cho Seong Whi  Yoon Bong-June  Lee Kyoung-Uk  Chae Jung-Ho  Choi Ihn-Geun  Ham Byung-Joo
Institution:Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea.
Abstract:Mood abnormalities related to major depressive disorder (MDD) seem to result from disturbances in pathways connecting the fronto-limbic and subcortical, both regions known to be involved in the processing of emotional information. Using functional magnetic resonance imaging (fMRI), we measured neural responses to viewing images of sad, angry and neutral faces in 21 patients with MDD and 15 healthy controls. When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the dorsolateral prefrontal cortex, inferior orbitofrontal cortex (OFC), medial OFC, caudate, and hippocampus. We also found significant group differences under the angry face condition, bilaterally, in the inferior OFC and medial OFC areas. Our findings indicate that decreased activations in the fronto-limbic and subcortical regions in response to affectively negative stimuli may be associated with pathophysiology of MDD.
Keywords:ROI  region of interest  MDD  major depressive disorder  ACC  anterior cingulate cortex  DLPFC  dorsolateral prefrontal cortex  OFC  orbitofrontal cortex  
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