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Lower 3H-imipramine binding in platelets from untreated depressed patients compared to healthy controls |
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| Authors: | Anna Wägner Anna Åberg-Wistedt Marie Åsberg Britta Ekqvist Björn Mårtensson Dolores Montero |
| Institution: | 1. Anna Wägner, M.D., Ph.D., Britta Ekqvist, B.S., and Dolores Montero, M.D., are in the Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, S-141 86 Huddinge, Sweden;2. Anna Åsberg-Wistedt, M.D., is in the Department of Psychiatry, Karolinska Institute, Danderyd University Hospital, S-182 30 Danderyd, Sweden;3. Marie Åsberg, M.D., and Björn Mårtensson, M.D., are in the Department of Psychiatry and Psychology, Karolinska Institute, Karolinska Hospital, S-104 01 Stockholm, Sweden |
| Abstract: | 3H-Imipramine binding in platelets was measured in 63 severely depressed hospitalized patients, who had been drug free (with the exception of moderate doses of benzodiazepines) for at least 1 month, and in 53 healthy control subjects of comparable age and sex distribution. Bmax of 3H-imipramine binding was significantly lower in the depressed subjects (1012 ± SD 295 vs. 1123 ± SD 178 fmole/mg protein). Depressed patients who had attempted suicide by violent means tended to have higher Bmax than nonviolent attempters. |
| Keywords: | platelets depressed patients suicide attempts |
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