近红外立体定向辅助导航大鼠模型研究

目的获取大鼠脑组织的近红外反射光谱,研究脑内灰、白质之间光谱曲线下面积的不同特征,探讨以此为指标判别脑内结构、辅助立体定向手术定位的可能性。方法将Y形双光纤探头步进插入大鼠脑内,采集穿刺轨迹不同位置的反射光谱,利用积分因子对采集结果进行统计分析。结果近红外光谱积分因子随探头前端脑组织性质发生明显变化,灰质内数值低,白质内数值高。结论采集光谱的积分因子能够有效的识别大鼠脑组织灰、白质,为脑组织光学定位的进一步研究提供了依据。

A study of near infrared spectroscopy in assisting stereotaxic neurosurgery of rat models

Objective To receive the near-infrared spectrum of the brain tissue in rats, and study the difference of the areas under the near-infrared spectral curves between gray and white matter, demonstrating the feasibility of using this index to identify different structures in the brain for guiding stereotaxic neurosurgery. Methods Insert a Y-shaped fiber optic probe into the brains of rats, collect the message of the reflectance spectrum from different spots along the trace of the probe, and analyze the collected data statistically with a integral factor. Results The integral factor of the near-infrared spectrum changed obviously in cooperation with the characteristics of different brain tissue before the fiber tip. It measured small when the tip went in gray matter, and measured large when in white matter. Conclusions The integral factor of the received spectrum can help identify gray and white matter effectively, which warrant further research in optical localization of the brain.