| A型肉毒毒素治疗口下颌肌张力障碍 |
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| 引用本文： | 卫华,王玉平,陈海,孙莹,李莉萍,邢华芳.A型肉毒毒素治疗口下颌肌张力障碍[J].脑与神经疾病杂志,2010,18(5). |
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| 作者姓名： | 卫华 王玉平 陈海 孙莹 李莉萍 邢华芳 |
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| 作者单位： | 首都医科大学宣武医院神经内科,北京,100053 |
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| 摘 要： | 目的观察A型肉毒毒素治疗口下颌肌张力障碍(OMD)患者的临床效果。方法对19例口下颌肌张力障碍患者进行临床分析,依据患者临床特点,将A型肉毒毒素注射到患者一侧或双侧咀嚼肌、颞肌及翼外肌,并根据肌肉收缩力量大小、肌肉体积及患者体重调整剂量。结果 68.4%的患者功能改善评分≥3分,疗效平均维持8～12周(有效范围2～28周)。4例患者注射后有轻度咀嚼无力,2～3周恢复。1例混合型患者注射后出现轻度鼻音,持续13天后症状消失。所有患者未出现其它严重副作用。结论 A型肉毒毒素对于口下颌肌张力障碍的治疗是有效、安全的。熟悉本病的临床特点及分型,选择正确的靶肌肉及注射适宜剂量的肉毒毒素是治疗本病的关键。
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| 关 键 词： | 口下颌肌张力障碍 肉毒毒素 闭口型肌张力障碍 |
Chinese botulinum toxin type A treatment in oromandibular dystonia |
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| WEI Hua,WANG Yu-ping,CHEN Hai,SUN Ying,LI Li-ping,XING Hua-fang.Chinese botulinum toxin type A treatment in oromandibular dystonia[J].Journal of Brain and Nervous Diseases,2010,18(5). |
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| Authors: | WEI Hua WANG Yu-ping CHEN Hai SUN Ying LI Li-ping XING Hua-fang |
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| Institution: | WEI Hua; WANG Yu-ping; CHEN Hai; SUN Ying; LI Li-ping; XING Hua-fang.Department of Neurology; Xuanwu Hospital; Capital Medical University; Beijing 100053; China; |
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| Abstract: | Objective To study different clinical manifestations of oromandibular dystonia(OMD)patients and the therapeutic efficacy of Chinese botulinum toxin type A(CBTX-A)in OMD patients.Methods This report described 19 patients with jaw-closing dystonia and mixed movement treated by injection of Chinese botulinum toxin type A(CBTX-A).Fourteen jaw-closing patients showed jaw clench,the other 5 mixed OMD patients showed jaw clench companied with its deviation to one side.CBTX-A was injected bilaterally or unilaterall... |
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| Keywords: | Oromandibular dystonia Botulinum toxin Jaw-closing dystonia |
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