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巴氯芬在中风后期的临床应用研究
引用本文:秦绍森,张晓燕,罗盛,王作为,刘明,陈海波.巴氯芬在中风后期的临床应用研究[J].脑与神经疾病杂志,2001,9(2):93-94.
作者姓名:秦绍森  张晓燕  罗盛  王作为  刘明  陈海波
作者单位:卫生部北京医院神经内科,
摘    要:目的:观察国产巴氯芬对中风后期伴肌张力增高患者的治疗效果及不良反应。方法:门诊就诊病程3月以上的中风伴肌张力增高的患者30例予以巴氯芬口服治疗。起始剂量为5mg,每日1次,3天后增加5mg,最大剂量每日小于80mg,维持治疗8周。服药前、后4周、8周检查血尿常规及肝肾功能。肌张力测定按国际通用的Ashworth评分,与治疗前相比肌张力恢复正常为痊愈。肌张力减低2级以上为显效,减低1级为有效。结果:除1例脱落外,余29例患者中显效9例,有效16例,总有效率为86.2%,而且未见明显毒副作用。结论:巴氯芬对脑血管病患者的偏瘫痉挛有较好效果,有利于偏瘫肢体的功能锻炼及康复。

关 键 词:中风  肌张力增高  巴氯芬  康复
修稿时间:2000年12月16

Clinical Use of Baclofen at the late stage of stroke
QIN Shaosheng,ZHANG Xiaoyan,LUO Sheng,et al..Clinical Use of Baclofen at the late stage of stroke[J].Journal of Brain and Nervous Diseases,2001,9(2):93-94.
Authors:QIN Shaosheng  ZHANG Xiaoyan  LUO Sheng  
Institution:QIN Shaosheng,ZHANG Xiaoyan,LUO Sheng,et al. Department of Neurology,Beijing Hospital,Beijing 100730
Abstract:Objective:To assess the efficacy and side effect of Baclofen in treating patients with hypertonia at the late stage of stroke. Methods: Thorty patients with hypertonia at the late stage of strole were treated with Baclofen (initial dosage:15mg/d, plus 5mg/d every 3 days, maximal dose: <80mg/d) for 8 weeks. Blood and Urine routine test, and hepatic and renal function were monitored before and 4 , 8 weeks after the treatment. Muscle tone was assessed according to Ashworth score. Complete recovery was considered if muscle tone ncrmdized, excellent efficacy if muscle tone decreased by two degrees, and good efficacy if muscle tone decreased by one degree. Results:Nine patients were found to have the decrease of muscle tone for more than 2 degrees, 16 patients for one degree. The total efficacy rate was 86.2%. The results indicate than Baclofen is effective in relieving suffered-limb spasm sfter cerebral vascular disorders. No side effect was observed. Conclusion: Baclofen is effective to patients with hypertonia at the late stage of stroke. It is beneficial to the rehabilitation and suffered-limb exercise.
Keywords:Stroke Hypertonia Baclofen Rehabilition
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