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| 脑梗死相关白质疏松患者磁共振波谱与认知功能关系的研究 | |
| 引用本文： | 张虹,屈秋民,张小玲,郭生龙,王全丽,杨谦,陈岩,何堪生,刘军.脑梗死相关白质疏松患者磁共振波谱与认知功能关系的研究[J].脑与神经疾病杂志,2010,18(1):12-15. |
| 作者姓名： | 张虹 屈秋民 张小玲 郭生龙 王全丽 杨谦 陈岩 何堪生 刘军 |
| 作者单位： | 1. 陕西省人民医院神经内科,西安,710068 2. 西安交通大学医学院第一附属医院神经内科 3. 陕西省人民医院磁共振室,西安,710068 4. 西安交通大学医学院公共卫生系 |
| 基金项目： | 陕西省科学技术研究发展计划(2009K18-02) |
| 摘 要： | 目的研究脑梗死患者白质疏松的磁共振波谱表现特点,以及白质疏松的磁共振波谱与认知功能的关系,为血管性认知功能障碍的早期识别及防治提供依据。方法选择51例脑梗死伴白质疏松患者及21例非白质疏松者进行简易智能状态测验(MMSE)、画钟试验测试、Fuld物体记忆测验(FOM)、快速词汇测验(RVR)及WAIS数字广度测验;同时行头颅磁共振成像(MRI)及双侧额叶白质的磁共振波谱(MRS)检查,测定N-乙酰天门冬氨酸(NAA)、肌酸(Cr)及胆碱(Cho)的浓度。分析白质疏松的MRS表现特点及其与认知功能障碍的关系。结果重度脑白质疏松组Cho/Cr值明显高于无、轻及中度疏松组;Cho/Cr值与白质疏松程度呈正相关;左侧额叶白质NAA/Cr值与MMSE评分及画钟试验评分正相关;右侧Cho/Cr值与WAIS数字广度测验评分负相关。结论双侧额叶白质区MRS改变主要为Cho/Cr值升高,并且与白质疏松程度正相关。血管性认知障碍与双额叶白质区神经纤维损害不一定完全一致。 |
| 关 键 词： | 白质疏松 磁共振成像 认知功能障碍 |
Research on relationship between magnetic resonance spectroscopy and cognitive function in patients with cerebral infarction-related leukoaraiosis |
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| ZHANG Hong,QU Qiu-min,ZHANG Xiao-ling,GUO Sheng-long,WANG Quan-li,YANG Qian,CHEN Yan,HE Kan-sheng,LIU Jun.Research on relationship between magnetic resonance spectroscopy and cognitive function in patients with cerebral infarction-related leukoaraiosis[J].Journal of Brain and Nervous Diseases,2010,18(1):12-15. | |
| Authors: | ZHANG Hong QU Qiu-min ZHANG Xiao-ling GUO Sheng-long WANG Quan-li YANG Qian CHEN Yan HE Kan-sheng LIU Jun |
| Institution: | ZHANG Hong,QU Qiu-min,ZHANG Xiao-ling,GUO Sheng-long,WANG Quan-li,YANG Qian,CHEN Yan,HE Kan-sheng,LIU Jun.Department of Neurology,the Shanxi Province People's Hospital,Xi'an 710068,China |
| Abstract: | Objective By researching magnetic resonance spectroscopy of cerebral infarction patients with leukoaraiosis,and relationship between magnetic resonance spectroscopy and cognitive function ,to provide evidences for earlier identification,prevention and trentment of patients with vascular cognitive impairment.Methods 51 patients with leukoaraiosis and 21 patients with non-leukoaraiosis were selected to be examed their cognitive function,including mini mental state examination(MMSE),clock drawing test (CDT),fu... |
| Keywords: | Leukoaraiosis Magnetic resonance imaging Cognitive impairment |
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