| EAE大鼠胸腺CD4~+ CD25~+ Foxp3~+ Treg细胞的动态变化及α-硫辛酸的干预作用 |
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| 引用本文： | 王燕燕,蔺辉前,檀国军,郭书英,张建娥.EAE大鼠胸腺CD4~+ CD25~+ Foxp3~+ Treg细胞的动态变化及α-硫辛酸的干预作用[J].脑与神经疾病杂志,2011,19(5):327-330. |
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| 作者姓名： | 王燕燕 蔺辉前 檀国军 郭书英 张建娥 |
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| 作者单位： | 河北医科大学第二医院神经内科,石家庄,050000 |
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| 基金项目： | 河北省自然科学基金资助项目(C090301) |
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| 摘 要： | 目的探讨实验性变态反应性脑脊髓炎(EAE)大鼠不同病程中胸腺CD4+CD25+Foxp3+Treg细胞变化情况及α-硫辛酸对EAE大鼠胸腺的干预作用。方法取不同时期对照组、自然病程EAE组及α-硫辛酸EAE组大鼠的胸腺组织做流式细胞学,动态检测CD4+CD25+Foxp3+Treg细胞的变化情况。结果 EAE组大鼠急性期、复发期CD4+CD25+Foxp3+Treg细胞较同时期对照组明显减少(P<0.05),缓解期有所上升;α-硫辛酸组与同期EAE组相比CD4+CD25+Foxp3+Treg细胞无明显变化;半年期三组大鼠胸腺CD4+CD25+Foxp3+Treg细胞都明显下降,各组间无统计学差异。结论 CD4+CD25+Foxp3+Treg细胞参与了EAE的发病,与病程的发展密切相关;α-硫辛酸对EAE大鼠的干预作用并非通过CD4+CD25+Foxp3+Treg细胞发挥其治疗作用;随着年龄的增长,胸腺不再是机体的主要免疫器官。
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| 关 键 词： | 实验性脑脊髓炎 胸腺 CD4+CD25+Foxp3+Treg细胞 α-硫辛酸 |
The variation of CD4~+ CD25~+ Foxp3~+ Tregulative cells of thymus in different courses of EAE group and the effection of alpha lipoic acid |
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| WANG Yan-yan,LIN Hui-qian,TAN Guo-jun,GUO Shu-ying,ZHANG Jian-e.The variation of CD4~+ CD25~+ Foxp3~+ Tregulative cells of thymus in different courses of EAE group and the effection of alpha lipoic acid[J].Journal of Brain and Nervous Diseases,2011,19(5):327-330. |
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| Authors: | WANG Yan-yan LIN Hui-qian TAN Guo-jun GUO Shu-ying ZHANG Jian-e |
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| Institution: | WANG Yan-yan,LIN Hui-qian,TAN Guo-jun,GUO Shu-ying,ZHANG Jian-e. Department of Neurology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
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| Abstract: | Objective To observe the variation of regulatory CD4+ CD25+ Foxp3+T cell(Treg) of thymus in different courses of experimental autoimmune encephalomyelitis(EAE) group,alpha lipoic acid(ALA) group and investigate the immune effect of ALA on the thymus of EAE.Methods Flow cytometry was used to analyze the expression rate of CD4+ CD25+ Foxp3+ Treg cells in the course of control group,EAE group and ALA group.Results In acute course and relapse course of EAE group,the expression of CD4+ CD25+ Foxp3+ Treg cells de... |
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| Keywords: | Experimental autoimmune encephalomyelitis Thymus CD4 CD25 Foxp3 T regulative cells Alpha lipoic acid |
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