| 盐酸多奈哌齐对血管性痴呆小鼠海马ERK1及ERK2表达变化的影响 |
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| 引用本文： | LU Pei-yuan,胡亚卓,GUO Zong-cheng,胡爱祥,李玲,梁翠萍,何春年,翟金萍.盐酸多奈哌齐对血管性痴呆小鼠海马ERK1及ERK2表达变化的影响[J].脑与神经疾病杂志,2008,16(2). |
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| 作者姓名： | LU Pei-yuan 胡亚卓 GUO Zong-cheng 胡爱祥 李玲 梁翠萍 何春年 翟金萍 |
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| 作者单位： | 1. 河北省人民医院神经内科,050051
2. 河北省人民医院病理科,050051 |
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| 基金项目： | 国家人事部留学人员科技活动择优资助项目 |
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| 摘 要： | 目的:探讨盐酸多奈哌齐对血管性痴呆(VD)小鼠海马中细胞外信号调节激酶(ERK1、ERK2)表达变化的影响。方法:采用双侧颈总动脉反复缺血-再灌注法制备小鼠VD模型。将小鼠随机分为假手术组、模型组及药物组,药物组给予盐酸多奈哌齐灌胃治疗。术后第29、30天,经跳台试验和水迷宫试验对各组小鼠进行行为学成绩测试,用免疫组化方法观察各组小鼠海马CA1区ERK1、ERK2的表达变化。结果:盐酸多奈哌齐明显改善了VD小鼠学习、记忆成绩(p<0.05)。模型组小鼠海马CA1区ERK1、ERK2表达较假手术组及治疗组减少,均有显著性差异(p<0.05)。结论:ERK1、ERK2的表达减少可能参与了血管性痴呆的发病机制,盐酸多奈哌齐通过增加乙酰胆碱含量,后者作用于毒蕈碱乙酰胆碱受体(M受体)激活ERK,有助于改善学习和记忆功能。
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| 关 键 词： | 血管性痴呆 小鼠 细胞外信号调节激酶 免疫组化 海马 |
The Effect of Donepezil Hydrochloride on the Changes about ERK1 and ERK2 at the Hippocampus of Mice with Vascular Dementia |
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| Institution: | LU Pei-yuan; HU Ya-zhuo; GUO Zong-cheng; et al Department of Neurology; Hebei Provincial People s Hospital; Shijiazhuang 050051; China; |
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| Abstract: | Objective:To observe the effect of donepezil hydrochloride on the changes about extracellular signal-regulated kinase(ERK1 and ERK2)at the hippocampus of mice with vascular dementia(VD).Methods:Kunming mice were divided into sham group,model group and treatment group with donepezil hydrochloride randomly.The models of VD mice were established through three times ischemia-reperfusion of bilateral common carotid arteries.The mice from drug group were treated with donepezil hydrochloride.The behavioral scores ... |
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| Keywords: | Vascular dementia Mice Extracellular signal-regulated kinase Immunohistochemistry Hippocampus |
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