| 银杏叶提取物治疗帕金森病大鼠的研究 |
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| 引用本文： | 曹非,孙圣刚,童萼塘,张敏.银杏叶提取物治疗帕金森病大鼠的研究[J].临床神经病学杂志,2003,16(5):281-283. |
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| 作者姓名： | 曹非 孙圣刚 童萼塘 张敏 |
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| 作者单位： | 1. 430022,武汉,华中科技大学同济医学院附属协和医院神经内科
2. 湖北省新华医院儿科 |
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| 基金项目： | 国家自然科学基金资助项目 (基金编号 :30 1 70 334) |
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| 摘 要： | 目的 观察银杏叶提取物 (EGb)治疗帕金森病 (PD)的效果 ,论证EGb治疗PD的可能性。方法 通过PD大鼠模型 ,采用免疫组织化学、HE染色、电镜及旋转行为检查的方法 ,观察模型成功后EGb(EGb组 )治疗 1天、7天、14天大鼠旋转行为及黑质病理变化 ,并与对照组 (PD组 )比较。结果 EGb组酪氨酸羟化酶染色显著高于PD组 (P <0 0 5 ) ,旋转圈数、黑质bFGF蛋白表达均较PD组减少 (均P <0 0 5 ) ,EGb组黑质超微结构及HE染色结构损伤均减轻。结论 银杏叶提取物可能是治疗PD的有效药物
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| 关 键 词： | 银杏叶提取物 药物治疗 帕金森病 大鼠 黑质 细胞形态学 行为学 |
| 文章编号： | 1004-1648(2003)05-0281-03 |
| 修稿时间： | 2003年4月24日 |
Study on the effect of treating Parkinson disease rats by Extract Ginkgo Bilobar |
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| Cao Fei,Sun Shenggang,Tong Etang,et al..Study on the effect of treating Parkinson disease rats by Extract Ginkgo Bilobar[J].Journal of Clinical Neurology,2003,16(5):281-283. |
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| Authors: | Cao Fei Sun Shenggang Tong Etang |
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| Institution: | Cao Fei,Sun Shenggang,Tong Etang,et al.Department of Neurology,Xiehe Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China |
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| Abstract: | Objective To observe the effect of treating Parkinson disease(PD) by Extract Ginkgo Bilobar(EGb) and demonstrate the possibility of EGb to treat PD Methods At 1d,7d,14d after PD rats model were succeded, rotational behaviour, immunohistochemistry,electronicmicroscopic were used to evaluate the role of EGb to treat PD Results On the group of EGb, the rotational behaviour and bFGF protein expression was lower,TH staining positive neurons was significantly more than the group of PD(all P <0 05).Electronicmicroscopic structure of the group of EGb were ameliorated effectively Conclusion EGb may be an effective drug to treat PD |
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| Keywords: | Parkinson disease Extract Ginkgo Bilobar |
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