脑出血患者血清基质金属蛋白酶水平与脑水肿和神经损害的关系

目的探讨脑出血患者血清基质金属蛋白酶(MMPs)水平与脑水肿和神经功能损害的关系。方法应用酶联免疫吸附法测定31例脑出血患者发病后1d、3d、7d和14d时血清MMP-9和MMP-2水平;发病当日及14d时头颅CT测定血肿及其周围脑水肿体积,同时进行卒中评分量表(NIHSS)评分。结果血清MMP-9、MMP-2水平发病后各时间点明显高于正常对照组(均P<0.05);发病7d及14d时MMP-9水平与血肿周围水肿体积呈正相关(r=0.748,P<0.001;r=0.436,P<0.05),与血肿体积及NIHSS评分无相关;各时间点MMP-2水平与血肿体积、血肿周围水肿体积及NIHSS评分无相关。结论脑出血后MMP-9过表达参与血肿周围水肿的形成。

Relationship between levels of serum matrix metalloproteinases and brain edema and neurologic impairment in patients with intracerebral hemorrhage

Objective To investigate the relationship between levels of serum matrix metalloproteinases(MMPs)and brain edema and neurologic impairment in patients with intracerebral hemorrhage(ICH).Methods The levels of serum MMP-9 and MMP-2 in 31 patients with ICH were tested with ELISA for at 1 d,3 d,7 d and 2 weeks after onset.The volumes of hematoma and its peripheral edema were evaluated by CT,the neurologic impairment was evaluated by NIHSS at 1 d and 14 d after onset.Results Levels of serum MMP-9 and MMP-2 were significant higher in ICH group at each time point after onset than those in normal control group(allP<0.05).Levels of serum MMP-9 at 7 d and 14 d after onset were positively related with brain edema volume(r=0.748,P<0.001,r=0.436,P<0.05).Both levels of serum MMP-9 and MMP-2 were not related with hematoma volume and NIHSS.The levels of serum MMP-2 was not related with brain edema volume.Conclusion Overexpressed MMP-9 after ICH is related with brain edema.