迟发性运动障碍患者血清铁调素、铁蛋白水平的研究

目的:探讨伴有迟发性运动障碍(TD)的精神分裂症患者血清铁调素(Hep)、铁蛋白(Fn)水平,以及铁代谢状况与TD的关系。方法:采用酶免疫法及化学发光法测定30例伴TD的精神分裂症患者(TD组)、41例不伴TD的精神分裂症患者(非TD组)及41名正常人(正常对照组)血清Hep、Fn水平;用异常不自主运动量表(AIMS)评估患者TD的严重程度及其与血清Hep、Fn水平的相关性。结果:TD组血清Hep水平低于非TD组及正常对照组(Z=-2.99,Z=-3.62;P均0.01),非TD组与正常对照组之间Hep水平差异无统计学意义(Z=1.22,P0.05);TD组血清Fn水平高于非TD组及正常对照组(Z=2.00,Z=2.39;P均0.05),非TD组与正常对照组之间Fn水平差异无统计学意义(Z=-0.70,P0.05)。TD组血清Hep水平与Fn水平呈负相关(r=-0.396,P0.05),AIMS评分与血清Hep及Fn水平无相关性(r=-0.052,r=0.14;P均0.05)。结论:TD患者存在铁代谢蛋白异常,铁代谢障碍可能参与了TD的病理生理过程。

Serum levels of hePcidin,ferritin in Patients with tardive dyskinesia

Objective:To explore the serum levels of hepcidin(Hep),ferritin( Fn)in schizophrenics with tardive dyskinesia(TD)as well as the relationship between iron metabolic status and TD. Method:Ser-um levels of Hep and Fn in 30 schizophrenics with TD(TD group),41 schizophrenics without TD(non-TD group)and 41 normal subjects(normal control group)were measured by enzyme immunoassay and chemilumi-nescence,respectively. Severity of TD was assessed with the abnormal involuntary movement scale(AIMS). Cor-relation of score of AIMS and serum level of Hep,Fn were analyzed. Results:Serum level of Hep in TD group was significantly lower than that in non-TD group and normal control group(Z = - 2. 99,Z = - 3. 62,all P <0. 01),while no difference was shown between non-TD group and normal control group(Z = 1. 22,P > 0. 05). Serum level of Fn in TD group was higher than that in non-TD group and normal control group(Z = 2. 00,Z =2. 39,all P < 0. 05),there was also no significant difference in serum level of Fn between non-TD group and normal control group(Z = - 0. 70,P > 0. 05). In TD group,serum level of Hep was negatively correlated with serum level of Fn(r = - 0. 396,P < 0. 05),no correlation existed between score of AIMS and serum level of Hep or Fn(r = - 0. 052,r = 0. 14;all P > 0. 05). Conclusion:TD patients have abnormal iron metabolic pro-tein. Iron metabolic disorder may be involved in the pathophysiological process of TD.