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| 皮质下缺血性血管性痴呆患者脑白质损害的磁共振弥散张量成像研究 | |
| 引用本文： | 付剑亮,常诚,李文彬,赵玉武.皮质下缺血性血管性痴呆患者脑白质损害的磁共振弥散张量成像研究[J].临床精神医学杂志,2011,21(2):94-96. |
| 作者姓名： | 付剑亮 常诚 李文彬 赵玉武 |
| 作者单位： | 1. 上海交通大学附属第六人民医院神经内科,200233 2. 上海交通大学附属胸科医院核医学科 3. 上海交通大学附属第六人民医院放射科 |
| 摘 要： | 目的:应用磁共振弥散张量成像技术(DTI)观察皮质下缺血性血管性痴呆(SIVD)患者脑白质损害程度,探讨DTI对SIVD白质损害的评估及与阿尔茨海默病(AD)鉴别诊断价值。方法:研究对象分为3组,分别是健康老年人(NC)、皮质下缺血性血管性痴呆(SIVD)患者、AD患者,每组各20例。行常规MR I和DTI扫描后,测定相同感兴趣区(RO I)的各向异性分数(FA)值和表观扩散系数(ADC)值进行比较。结果:SIVD组下额枕束、胼胝体膝部、胼胝体压部、上纵束等部位FA值下降,ADC值升高,与NC、AD组比较差异有统计学意义(P<0.05)。与NC组比较,AD组前额叶、颞叶、海马、下额枕束、胼胝体膝部和扣带束等部位FA值降低,颞叶、海马等部位ADC值升高,两组差异具有显著性(P<0.05);结论:DTI可以用来评估痴呆患者白质损害的程度,SIVD患者以下额枕束、胼胝体膝部、胼胝体压部、上纵束等部位受累为主,可作为与AD鉴别的客观指标。 |
| 关 键 词： | 血管性痴呆 阿尔茨海默病 弥散张量成像 各向异性分数 表观扩散系数 |
The value of diffusion tensor imaging in evaluating the changes of microstructural integrity of white matter in suscortical ischemic vascular dementia patients |
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| FU Jian-liang,CHANG Cheng,LI Wen-bin,ZHAO Yu-wu.The value of diffusion tensor imaging in evaluating the changes of microstructural integrity of white matter in suscortical ischemic vascular dementia patients[J].Journal of Clinical Psychological Medicine,2011,21(2):94-96. | |
| Authors: | FU Jian-liang CHANG Cheng LI Wen-bin ZHAO Yu-wu |
| Institution: | FU Jian-liang,CHANG-Cheng,LI Wen-bin,ZHAOYu-wu.Department of Neurology,No.6 Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China |
| Abstract: | Objective: To evaluate the diagnostic and differential diagnosis value of microstructural integrity of white matter(WM) changes in patients with subcortical ischemic vascular dementia(SIVD) using diffusion tensor imaging(DTI). Method:Three groups were identified to normal control(NC) group,Alzheimer's disease(AD) group and SIVD group for 20 cases each.After routine MRI and DTI were completed,FA and ADC values were measured and compared on regions of interest(ROI). Results:Compared to NC and AD group,there w... |
| Keywords: | vascular dementia Alzheimer's disease diffusion tensor imaging fractional anisotropy apparent diffusion coefficient |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |