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奥氮平与氯氮平治疗精神分裂症的对照研究
引用本文:王晓龙,李益民,胡颖萃,梅其一.奥氮平与氯氮平治疗精神分裂症的对照研究[J].临床精神医学杂志,2008,18(5):305-306.
作者姓名:王晓龙  李益民  胡颖萃  梅其一
作者单位:江苏苏州市广济医院,215008
摘    要:目的:比较奥氮平与氯氮平治疗精神分裂症的疗效及改善社会功能的作用。方法:将70例精神分裂症患者随机分为奥氮平组或氯氮平组。治疗6个月后,采用阳性与阴性症状量表(PANSS)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应,以社会功能缺陷量表(SDSS)评定社会功能。结果:两组患者治疗前后PANSS总分及各因子分比较差异均无显著性;奥氮平的过度镇静及抗胆碱能不良反应较少;治疗6个月后SDSS评定,在职业工作、婚姻职能、父母职能、社会性退缩、责任心和计划方面及总分,奥氮平组显著优于氯氮平组。结论:两组疗效相当,但奥氮平不良反应较少,对改善患者的社会功能明显优于氯氮平,有利于患者适应社会生活。

关 键 词:精神分裂症  奥氮平  氯氮平  社会功能

A comparative study between olanzapine and clozapine in treatment of schizophrenia
WANG Xiao-long,LI Yi-min,HU Ying-cui,MEI Qi-yi.A comparative study between olanzapine and clozapine in treatment of schizophrenia[J].Journal of Clinical Psychological Medicine,2008,18(5):305-306.
Authors:WANG Xiao-long  LI Yi-min  HU Ying-cui  MEI Qi-yi
Institution:WANG Xiao-long,LI Yi-min,HU Ying-cui,MEI Qi-yi.Suzhou Guangji Hospital,Suzhou 215008,China
Abstract:Objective:To compare the efficacy between olazapine and clozapine in the treatment of schizaphrenia,and then to compare the improvement of social functions. Method:Seventy schizophrenic patients were randomly divided into olanzapine group and clozapine group.All the patients were evaluated with positive and negative symptom scale(PANSS),treatment emergent symptom scale(TESS) and social disability screening schedule(SDSS) after treatment for 6 weeks. Results:At baseline and after treatment,the total scores and factor scores of PANSS had no sigmificant differences in the two groups.Olanzapine had less execess calmness and anticholinergy than clozapine.After 6 months of treatment,the scores of profession,marriage,parental responsibility,social withdraw,responsibility,plan and total scores of SDSS in olazapine group were significantly better than that in clozapine group. Conclusion:The efficacy of both groups are similar,but olanzapine group has less side effects and significantly overwins clozapine in improving social function which benefits schizophrenic patients in social life.
Keywords:schizaphrenia  olanzapine  clozapine  social function
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