坦度螺酮与多虑平治疗焦虑症对照研究

目的：比较坦度螺酮与多虑平治疗焦虑症的疗效和不良反应。方法：60例焦虑症患者随机分为坦度螺酮组和多虑平组，每组各30例;分别给予坦度螺酮和多虑平治疗。疗程4周。于治疗前及治疗1、2、4周采用汉密尔顿焦虑量表（HAMA）和治疗中出现的症状量表（TESS）评定临床疗效和不良反应。结果：坦度螺酮组总有效率和显效率分别为83.3%和46.7%，明显高于多虑平组的60.0%和36.7%（P〈0.05）;坦度螺酮组和多虑平组HAMA评分治疗前分别为（28.3±6.1）分和（29.2±5.7）分，治疗4周，分别下降至（10.9±4.6）分和（15.8±5.1）分，两组均有效但以坦度螺酮组显著为好（P〈0.05）。两组不良反应发生率以坦度螺酮组较多虑平组少而轻。结论：坦度螺酮治疗焦虑症疗效明显好于多虑平，显效快，不良反应少。

Tandospirone vs Doxepin in treating anxiety neurosis

Objective:To compare the effects and adverse reactions of tandospirone and doxepin in treating anxiety neurosis. Method:60 cases with anxiety neurosis were randomly divided into two groups(tandospirone and doxepin).Effects and adverse reactions were evaluated with hamiltom anxiety scale(HAMA)and treatment emergent symptoms scale(TESS) before and after treatment. Results:The marked effective rate and total effective rate were 46.7% and 83.3% respectively in tandospirone group and were significantly higher than those in doxepin group 36.7 and 60.0% respectively(P<0.05),The adverse reactions in tandospirone group were less than those in doxepin group. Conclusion: Tandospirone shows better and faster efficacy and less adverse reactions than doxepin in treating anxiety neurosis.