精神分裂症患者认知功能损害与阴阳性症状的关系

目的：探讨精神分裂症认知功能损害与阴性、阳性症状的关系。方法:至73例入组的患者随机给予利培酮、氯氮平治疗12周，并于治疗前、后盲法评定Wisconsin卡片分类测验（WCST），Wechsler记忆测验（WMS）,阴状症状评定量表（SANS）与阳性症状评定量表（SAPS）。结果：治疗前精神分裂症患者的阴性症状、阳性症状均与认知功能有显著相关。主要与执行功能相关；注意障碍与记忆相关。治疗后，仅SAPS中怪异行为得分与WCST的持续反应数、持续错误数显著相关。结论：精神分裂症的认知功能损害是原发性的，并不是在阳性、阴性症状基础上产生的。

The relationship of schizophrenic cognitive function impairment with positive and negative symptoms

Objective:To explore the relationship between cognitive function impairment and negative and positive symptoms in schizophrenic patients. Method:73 schizophrenic patients were treated randomly with risperidone or clozapine for 12 weeks.They were assessed with WCST,WMS,SANS and SAPS separately before and after 12 weeks treatment. Results:Both negative and positive symptoms before treatment were significantly correlated with cognitive symptoms.They were correlated mainly with executive function;Attention impairment was correlated with memory.After treatment,only bizarre behaviour of SAPS was correlated with perseverative respond and perseverant errors of WCST.Conclusion:Cognitive function impairment of schizophrenia is a primary symptom which is not based on negative and positive symptoms.