| 抑郁症自杀未遂患者若干生物学改变 |
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| 引用本文： | 冀德才,于彩霞,田宝阁,刘艳杰,黄敏.抑郁症自杀未遂患者若干生物学改变[J].临床精神医学杂志,2009,19(4). |
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| 作者姓名： | 冀德才 于彩霞 田宝阁 刘艳杰 黄敏 |
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| 作者单位： | 1. 吉林吉林市精神病医院,132011
2. 大连医科大学 |
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| 摘 要： | 目的:探讨抑郁症自杀未遂患者外周血中CD4+CD25+调节性T(Tr)细胞、白细胞介素2(IL-2)及IL-6水平与自杀行为间的关系。方法:患者组为44例抑郁症自杀未遂患者,对照组为30名健康正常者。患者组用选择性5-羟色胺再摄取抑制剂或文拉法辛治疗。治疗前后检测CD4+CD25+Tr、IL-2及IL-6。采用自杀未遂调查表评定两组严重程度。结果:患者组治疗前外周血中CD4+CD25+Tr、IL-2及IL-6均显著高于对照组(P<0.05或P<0.01)。患者组治疗后外周血中CD4+CD25+Tr、IL-2显著降低(P<0.01),IL-6变化不明显。两组比较差异无统计学意义(P>0.05)。患者病情严重程度与血中CD4+CD25+Tr、IL-2、IL-6水平均无显著相关。结论:抑郁症自杀未遂患者处于免疫紊乱状态,CD4+CD25+Tr、IL-2、IL-6与自杀行为间存在一定的关系。
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| 关 键 词： | 抑郁症 自杀未遂 CD4+CD25+Tr细胞 白细胞介素2 白细胞介素6 |
A study on the CD4+ CD25+ Tr, interleukin-2 and interleukin-6 in the peripheral blood of suicide attempters with depression |
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| JI De-cai,YU Cai-xia,TIAN Bao-ge,LIU Yan-jie,HUANG Min.A study on the CD4+ CD25+ Tr, interleukin-2 and interleukin-6 in the peripheral blood of suicide attempters with depression[J].Journal of Clinical Psychological Medicine,2009,19(4). |
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| Authors: | JI De-cai YU Cai-xia TIAN Bao-ge LIU Yan-jie HUANG Min |
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| Institution: | JI De-cai,YU Cai-xia,TIAN Bao-ge,LIU Yan-jie,HUANG Min.Jilin Mental Hospital,Jilin 132011,China |
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| Abstract: | Objective:To explore the relationship between the level of CD4+CD25+ regulatory T cells(Tr),interleukin-2(IL-2),interleukin-6(IL-6)in the peripheral blood and suicidal behavior in attempted suicidal patients suffered from depression.Method:44 cases of depression with attempted suicide were recruited as the patient group and 30 normal people as the control group.The CD4+CD25+ Tr cells were analyzed by the flow cytometry and the concentration of IL-2 and IL-6 were detected by ELISA.Results:Compared with the c... |
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| Keywords: | depression suicidal attempters CD4+CD25+ regulatory T cells interleukin-2 interleukin-6 |
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