氯氮平对超敏C反应蛋白及糖脂代谢的影响

目的：探讨氯氮平对精神分裂症患者超敏C反应蛋白（hs-CRP）以及糖、脂代谢的影响。方法：对30例服用氯氮平治疗的精神分裂症患者（患者组）作hs-CRP、空腹血糖、三酰甘油、胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）检测，于治疗前、治疗第4、8、12周各检测1次。并与30名健康者（对照组）进行比较。结果：治疗前患者组和对照组糖脂各值差异无显著性。在治疗第4、8、12周的hs-CRP，第12周的空腹血糖、三酰甘油、胆固醇、LDL、ApoB比治疗前明显升高；治疗第12周的HDL、ApoA1比治疗前明显下降；hs-CRP与空腹血糖、三酰甘油、胆固醇以及氯氮平剂量呈正相关。结论：氯氮平对hs-CRP、糖脂代谢均会产生影响，氯氮平导致代谢综合征可能与hs-CRP有关。

Effect of clozapine on high-sensiavity C-reactive protein and metabolism of glucose and lipid

Objective:To explore the effect of clozapine on high-sensitivity C-reactive protein(hs-CRP)and metabolism of glucose and lipids in patients with schizophrenia.Method:Hs-CRP,fasting plasma glucose,triglyceride,cholesterol,high density lipoprotein cholesterol(HDL),low density lipoprotein cholesterol(LDL),apoprotein A1(ApoA_1)and apoprotein B(ApoB)were measured in thirty patients with schizophrenia treated with clozapine(patient group)before and after treatment 4,8,12 weeks and in thirty healthy controls(control group).Results:There were no significant difference between the two groups for all indices above before treatment.For patients with schizophrenia,hs-CRP at 4,8 and 12 weeks increased obviously compared with that before treatment.Fasting plasma glucose,triglyceride,cholesterol,LDL,apoB at 12 weeks increased significantly,and HDL and ApoA_1 at 12 weeks lowed significantly than those at baseline.The level of hs-CRP was positively correlated with fasting plasma glucose,triglyceride,cholesterol and dosage of clozapine.Conclusion:Clozapine has effects on hs-CRP and metabolism of glucose and lipid.Metabolism syndrome induced by clozapine may relate to hs-CRP.