| 抗精神病药对代谢的影响比较 |
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| 引用本文： | 汪卫华,赵汉清,王焕林,崔庶,汪广剑,仲爱芳,宋梓祥,闫同军,薛蕴庄.抗精神病药对代谢的影响比较[J].临床精神医学杂志,2009,19(1). |
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| 作者姓名： | 汪卫华 赵汉清 王焕林 崔庶 汪广剑 仲爱芳 宋梓祥 闫同军 薛蕴庄 |
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| 作者单位： | 1. 解放军第102医院精神科,常州,213003
2. 解放军第102医院化验科,常州,213003 |
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| 摘 要： | 目的:探讨抗精神病药对体质量、血糖、血脂、胰岛素、瘦素的影响。方法:首发住院精神分裂症患者94例随机分为3组,分别服用氯氮平、利培酮、奥氮平治疗,于治疗前和治疗6周测定体质量、血清瘦素、胰岛素、胰岛素抗体、空腹血糖、糖化血红蛋白(HbA1c)、血清胆固醇(TC)及三酰甘油(TG)。结果:3组治疗前后BMI变化分别为(2.37±2.11)kg/m2、(1.32±1.77)kg/m2、(2.07±1.38)kg/m2(F=10.783,P=0.000)。治疗前3组糖化血红蛋白差异显著(F=16.412,P<0.001),初始血糖、初始TC、TG、胰岛素、瘦素水平差异无显著性(P>0.05)。治疗6周后,3组间血糖、初始TC、TG、胰岛素、瘦素水平均有显著性差异。结论:氯氮平对体质量、血糖、血脂、瘦素及胰岛素的影响大;奥氮平不良反应较小,对体质量、血脂、血浆瘦素水平影响较大;利培酮对各项代谢指标及体质量的影响较小。
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| 关 键 词： | 抗精神病药 精神分裂症 体质量增加 瘦素 胰岛素 |
The Comparison of metabolic effects of antipsychotic drugs |
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| WANG Wei-hua,ZHAO Han-qing,WANG Huan-lin,Cui Su,WANG Guang-jian,ZHONG Ai-fang,SONG Zhi-xiang,YAN Tong-jun,XUE Yun-zhuang.The Comparison of metabolic effects of antipsychotic drugs[J].Journal of Clinical Psychological Medicine,2009,19(1). |
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| Authors: | WANG Wei-hua ZHAO Han-qing WANG Huan-lin Cui Su WANG Guang-jian ZHONG Ai-fang SONG Zhi-xiang YAN Tong-jun XUE Yun-zhuang |
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| Institution: | WANG Wei-hua,ZHAO Han-qing,WANG Huan-lin,Cui Su,WANG Guang-jian,ZHONG Ai-fang,SONG Zhi-xiang,YAN Tong-jun,XUE Yun-zhuang.Department of Psychiatry,the 102nd hospital of PLA,Changzhou 213003,China |
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| Abstract: | Objective:To explore the effects of antipsychotic drugs on patients body weight,leptin,insulin,fasting plasma glucose and triglyceride.Method:94 first-episode schizophrenia inpatients were recruited,treated by clozapine,risperidone and olanzapine in three groups.The body weight,serum leptin,insulin,insulin antibody,fasting plasma glucose,glycosylated hemoglobin(HbA1c),total cholesterol(TC)and triglyceride(TG)were examined before treatment and after 6 week treatment respectively.Results:The body weight index... |
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| Keywords: | antipsychotic drug schizophrenia weight gain leptin insulin |
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