二甲双胍治疗抗精神病药所致高催乳素血症患者的初步观察

目的：探讨二甲双胍对抗精神病药所致高催乳素血症（HPRL）的治疗效果。方法：选择抗精神病药治疗过程中出现HPRL的住院精神疾病患者共24例，给予二甲双胍0．75g/d口服，观察12周。分别于治疗前和治疗4周、8周和12周后测定PRL水平。结果：24例患者二甲双胍治疗前PRL水平平均（80．62±56．26）ng/ml，治疗4周后PRL水平降至（62．94±43．49）ng／ml，平均降低（17．69±25．30）ng/ml，治疗前后比较，差异有统计学意义（t=3．424，P〈0．01）。结论：二甲双胍对于抗精神病药所致HPRL可能具有降低PRL的作用。

Preliminary observation of the metformin efficacy for hyper-prolactinemia induced by antipsychotics

Objective：This study explores the efficacy of metformin for hyperprolactinemia （HPRL）in- duced by antipsyehotic. Method：24 psychiatric patients with hyperprolactinemia induced by antipsyehotics were chosen as a sample group in which each patient was given O. 75 g of mefformin per day for 12 weeks. The serum prolactin level was assessed befor and after treatment for 4 weeks,8 weeks,12 weeks. Results：The ser- um prolactin level was （ 62.94±43.49） ng/ml, compared with （ 80.62 ± 56.26） ng,/ml before the medication, there is an average decrease of （17.69±25.30）ng/ml in the serum prolactin level （t = 3. 424 ,P 〈 0.01 ）. Conclusion：The results show that metformin may have a therapeutic effect on decreasing the serum prolaetin level in patients with hyperprolactinemia induced by antipsychotics.