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氟西汀合并奥氮平治疗难治性抑郁症对照研究
引用本文:王彬,胡峻梅,李宝花,张校明.氟西汀合并奥氮平治疗难治性抑郁症对照研究[J].山东精神医学,2006,19(2):87-89.
作者姓名:王彬  胡峻梅  李宝花  张校明
作者单位:四川大学华西基础医学与法医学院司法精神病学教研室,四川大学华西基础医学与法医学院司法精神病学教研室,四川大学华西基础医学与法医学院司法精神病学教研室,山东省济宁市精神病防治院
摘    要:目的探讨小剂量奥氮平合并氟西汀治疗难治性抑郁症的疗效和不良反应。方法将74例难治性抑郁症患者随机分为2组,研究组在氟西汀(20mg/d)治疗的同时合并应用奥氮平(5~10mg/d);对照组仅用氟西汀(20mg/d)治疗,两组作4周的持续治疗观察,于入组前及入组后第1、2、4周末分别用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)及副反应量表进行评定。结果两组在治疗后第2、4周末,HAMD、HAMA总分及减分率的差异有统计学意义,两组间有效率的差异也有统计学意义。研究组和对照组分别有48.5%和38.9%出现不良反应,差异无统计学意义。结论小剂量奥氮平在难治性抑郁症的治疗中有增效作用,优于单用氟西汀,且安全性较好,在临床上可以作为治疗难治性抑郁症的一个备选方案。

关 键 词:难治性抑郁症  氟西汀  奥氮平
文章编号:1009-7201(2006)-02-0087-03
收稿时间:2006-03-27
修稿时间:2006年3月27日

A clinical comparative study of olanzapine augmented with fluoxetine on the refractory depression
WANG Bin,HU Jun-mei,LI Bao-hua,et al..A clinical comparative study of olanzapine augmented with fluoxetine on the refractory depression[J].Shangdong Archives of Psychiatry,2006,19(2):87-89.
Authors:WANG Bin  HU Jun-mei  LI Bao-hua  
Institution:WANG Bin,HU Jun-mei,LI Bao-hua,et al.The school of Basic Medical and Forensic Medicine in West China Medical Center of Sichuan University,Chengdu 610041,China
Abstract:ObjectiveTo explore the effects of low-dose olanzapine combining with fluoxetine on the refractory depression.Methods A total of 74 patients with the refractory depression were randomly assigned to the two groups:a low-dose (5~10mg/d)of olanzapine with fluoxetine or fluoxetine alone.They were evaluated with Hamilton Depression Scale (HAMD),Hamilton Anxiety Scale (HAMA),and Treatment Emergent Symptom scale (TESS) before treatment and at the end of 1st,2nd,4th week after treatment.The study last for 4 weeks.Results There were significant differences on the scores of HAMD and HAMA between the two groups at the end of 2nd and 4th week after treatment.The effective rate had significant difference between two groups,48.5% of patients in study group showed mild side effects ,in comparison with 38.9% in control group.Conclusion Olanzapine may be effective and safe in the treatment of refractory depression.
Keywords:Refractory depression Fluoxetine Olanzapine
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