儿童孤独症早期干预效果及影响因素研究

目的 探讨早期综合干预对儿童孤独症的效果及影响因素.方法 对82例孤独症儿童采取综合干预,干预前后分别应用儿童孤独症评定量表（CARS）、0-6岁儿童神经心理发育量表、儿童孤独症及相关发育障碍心理教育量表修订版（C-PEP）进行测查.结果 CARS量表评分干预后显著低于干预前（p=0.000）;发育商干预后显著高于干预前（P=0.000）;干预后C-PEP的功能发展量表中所有项目评分及发展总分均较干预前显著升高,病理学量表中所有项目评分均较干预前显著下降（P＜0.01）.多元逐步回归分析结果显示,38项自变量中的6项进入CARS评分变化的回归方程（P＜0.05）,9项进入发育商变化的回归方程（P＜0.05）.结论 早期综合干预能有效减轻孤独症患儿的病理症状,提升发育水平.

Effect of early intervention on children with autism and its influencing factors

Objective To explore the effect of early comprehensive intcrvention on children with autism and its influencing factors. Methods 82 children with autism were treated with comprehensive intervention for 1 year. All children were assessed with CARS, the Neuropsychological Development Examination Table for Children Aged 0-6 Years Old, C-PEP at baseline and at the end of the 1-year intervention. Results Score of CARS decreased significantly after l-year intervention （ P ： 0. 000 ）. Development quotient at the end of the intervention was significantly higher than that at baseline （ P = 0. 000 ）. Compared with baseline, the total score and all item scores of function development subscale in C-PEP increased significantly, and all item scores of pathology subscale in C-PEP decreased significantly （ P 〈 0. 01 ）. Multiple stepwise regression analysis with 38 independent variables showed that 6 independent variables entered the regression equation of score of CARS （ P 〈 0. 05 ） , and 9 independent variables entered the regression equation of development quotient （P 〈 0.05 ）. Conclusion Early comprehensive intervention can effectively improve the pathological symptoms of autism, enhance the level of development.