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奥氮平和利培酮治疗精神分裂症临床对照研究
引用本文:刘广敬,潘世丽,王学刚,张红霞,于新萍.奥氮平和利培酮治疗精神分裂症临床对照研究[J].山东精神医学,2009,22(1):30-32.
作者姓名:刘广敬  潘世丽  王学刚  张红霞  于新萍
作者单位:山东省聊城市第四人民医院,252000  
摘    要:目的比较奥氮平和利培酮对精神分裂症的治疗效果和安全性。方法以奥氮平与利培酮对120例精神分裂症患者进行为期6周的对照治疗,采用阳性和阴性症状量表(PANSS)评定疗效,用副反应量表(TESS)评定副反应。结果奥氮平组显效率76.7%,有效率95%;利培酮组显效率76.7%。有效率93%。奥氮平的主要副反应为嗜睡,利培酮的主要副反应为锥体外系反应。结论两药治疗精神分裂痘均有良好疗效.且安全性较高。

关 键 词:奥氮平  利培酮  精神分裂症

A comparative study of olanzapine and risperidone in the treatment of schizophrenia
Institution:LIU Guangjing,PAN Shili, WANG Xuegang, et al. (The Forth People's Hospital of Liaocheng City, Liaocheng 252000,China)
Abstract:Objective To compare the clinical efficacy and safety between olanzapine and risperidone in the treatment of patients with schizophrenia. Methods A total of 120 patients with schizophrenia were randomly assigned into olanzapine group and risperidone group for the treatment of 6 weeks. The Positive and Negative Symptoms Scale (PANSS) was used to evaluated the efficacy, and the Treatment Emergent Symptoms Scale (TESS) was used to assess the side effects. Results The response rates were 95% for olanzapine group and 93% for risperidone group. The main side effects of olanzapine was somnolence, and those of risperidone was EPS. Conclusion Both olanzapine and risperidone are effective and safe in the treatment of schizophrenia.
Keywords:Olanzapine Risperidone Schizophrenia
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