伴月经紊乱的女性精神分裂症患者换用阿立哌唑后一年随访

目的探讨因服用其他抗精神病药物而出现月经紊乱的女性精神分裂症患者换用阿立哌唑后的月经变化，疗效及安全性。方法对30例经抗精神病药物治疗而出现月经紊乱的女性精神分裂症患者，换用阿立哌唑单一治疗52周，在2周内停用原抗精神病药物。观察月经及溢乳情况，应用阳性和阴性症状量表（PANSS）、副反应量表（TESS）进行评定。结果阿立哌唑治疗后，19例闭经者中18例（94．74％）月经来潮，月经量正常且恢复月经周期。11例月经不规律者中10例（90．91％）明显改善。7例溢乳者的溢乳消失。PANSS评分自第4周始明显下降，差异有极显著性（P〈0．01），在整个研究过程中无严重不良反应发生。结论经换用阿立哌唑治疗后，94．74％的闭经患者恢复正常月经，90．91％的月经不规律患者明显改善。但其对内分泌的影响及长期疗效还有待进一步观察。

A one-year follow-up study of female schizophrenic patients with menstrual disturbance after switching to aripiprazole.

Objective To explore the efficacy and safety of aripiprazole in the treatment of female schizophrenic patients with antipsychotics-induced menstruation disturbances.Methods Thirty female schizophrenic patients with antipsychotics-induced menstruation disturbance were switched to aripiprazole of treatment for 52 weeks.The menses status and galactorrhea were observed.Positive and Negative Symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS) were used to evaluate the efficacy and side effects.Result...