| 大鼠急性脑缺血再灌注损伤精氨酸加压素变化和脑水肿实验研究 |
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| 引用本文： | 徐忠信,杨宏,钱佳利,赵力.大鼠急性脑缺血再灌注损伤精氨酸加压素变化和脑水肿实验研究[J].中风与神经疾病杂志,1995(4). |
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| 作者姓名： | 徐忠信 杨宏 钱佳利 赵力 |
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| 作者单位： | 长春白求恩医大三院神经内科 |
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| 摘 要： | 应用大鼠急性脑缺血再灌注动物模型，观察精氨酸加压素（ＡＶＰ）在急性脑缺血再灌注损伤中的变化及与脑水肿关系，结果表明丘脑下部ＡＶＰ含量在脑缺血３０ｍｉｎ明显增加，再灌注６０ｍｉｎ后进一步增加，且与大脑皮层水含量是显著相关性。提示，ＡＶＰ参与急性脑缺血再灌注损伤，丘脑下部ＡＶＰ含量增高，可加重或促进脑缺血再灌注后脑水肿形成。
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| 关 键 词： | 脑缺血再灌注，精氨酸加压素，脑水肿 |
The experiment research of acute cerebral ischemia and reperfusion injury of rats AVP and brain edema. |
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| Xu Zhongxin, Yang Hong,Qian Jiali,et al.The experiment research of acute cerebral ischemia and reperfusion injury of rats AVP and brain edema.[J].Journal of Apoplexy and Nervous Diseases,1995(4). |
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| Authors: | Xu Zhongxin Yang Hong Qian Jiali |
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| Abstract: | The model of acute cerebral ischemia and reperfusion injury on rats was observed the change of AVP in acute cerebral ischemia and reperfusion injury of rats and it contact with brain edema. The results showed that the contents of AVP in hypothalamus increased significantly for 30 minutes after ischemia,increased further for 60 minutes after reperfusion and interrelated with the contents of cerebral cortex. These suggested the AVP was involved in acute reperfusion injury following cerebral ischmia. The increasing of AVP contents in hypothalamus could prove the formation of brain edema. |
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| Keywords: | Cerebral ischemia and reperfusion AVP Brain edema |
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