| 颞叶癫痫患者警觉功能的脑功能磁共振研究 |
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| 引用本文： | 覃百灵,郑金瓯,党超,叶伟,陈子蓉,余璐.颞叶癫痫患者警觉功能的脑功能磁共振研究[J].中风与神经疾病杂志,2011,28(10). |
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| 作者姓名： | 覃百灵 郑金瓯 党超 叶伟 陈子蓉 余璐 |
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| 作者单位： | 1. 南宁市第二人民医院神经内科,广两南宁,530031
2. 广两医科大学第一附属医院神经内科,广西南宁,530021 |
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| 基金项目： | 广西科学研究与技术开发计划项目(桂科攻0993003C-20) |
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| 摘 要： | 目的利用注意网络测试(ANT)软件和功能核磁共振(fMRI)成像技术探讨颞叶癫痫(TLE)患者的警觉网络功能特点、激活模式及其脑功能状态。方法对12例TLE患者及匹配的8名健康志愿者进行研究。使用ANT软件进行警觉功能行为学测试,记录反应时间(RT);并采用ANT改良的警觉网络功能组块模式fMRI扫描,fMRI数据采用统计参数图(SPM2)软件分析。结果 TLE患者组与健康对照组ANT警觉网络功能的反应时间无差异。健康对照组警觉网络fMRI显示右枕叶、小脑明显激活;右边缘叶、右额叶及左侧颞叶、脑干部分激活。TLE患者组存在相同警觉网络相关脑区,但激活明显减弱且颞叶和脑干无激活。结论健康对照警觉网络功能与右侧枕叶、小脑、右额叶、脑干及颞叶等脑区相关。TLE患者存在警觉网络相关脑区功能明显低下,可能是TLE患者出现警觉功能损害的脑功能基础。
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| 关 键 词： | 注意网络测试 功能磁共振成像 颞叶癫痫 警觉网络 |
The functional magnetic resonance imaging investigation of the alerting network in patient with temporal lobe epilepsy |
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| QIN Bai-Ling,ZHENG Jin-Ou,DANG Chao,et al..The functional magnetic resonance imaging investigation of the alerting network in patient with temporal lobe epilepsy[J].Journal of Apoplexy and Nervous Diseases,2011,28(10). |
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| Authors: | QIN Bai-Ling ZHENG Jin-Ou DANG Chao |
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| Institution: | QIN Bai-Ling,ZHENG Jin-Ou,DANG Chao,et al.(Department of Neurology,The Affiliated Hospital,Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Objective To investigate the characteristic and neural basis of the alerting network function in patients with temporal lobe epilepsy(TLE) by performing the attentional networks test(ANT) and functional magnetic resonance imaging(fMRI).Methods The computerize ANT software were performed in 12 patients with TLE and 8 healthy volunteers,and the reaction time(RT) was recorded.Block design fMRI was used to acquire resource data by an adapted ANT alerting network test used as target stimulus.Image analysis was p... |
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| Keywords: | Functional magnetic resonance imaging(fMRI) Attentional networks test(ANT) Temporal lobe epilepsy(TLE) The alerting network |
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