缺血性脑血管病合并不宁腿综合征危险因素分析

目的筛查缺血性脑血管病合并不宁腿综合征的相关危险因素。方法共370例首次发作的缺血性脑血管病患者根据是否合并不宁腿综合征,分为缺血性脑血管病合并不宁腿综合征组(不宁腿综合征组,45例)和不合并不宁腿综合征组(无不宁腿综合征组,325例),详细记录性别、年龄、体重指数、受教育程度、民族、职业、生活方式、体育锻炼、既往史、女性孕产史和绝经年龄;血液化学检测白细胞计数、血红蛋白、血清肌酐、尿素氮、空腹血糖、血清脂质、血浆同型半胱氨酸、血清铁等。结果不宁腿综合征组体重指数高于无不宁腿综合征组(t=2.457,P=0.014),血红蛋白(t=2.819,P=0.005)和血清铁(t=2.168,P=0.024)低于无不宁腿综合征组。多因素前进法Logistic回归分析显示,血红蛋白降低(OR=1.049,95%CI:1.017~1.082;P=0.002)和血清铁降低(OR=1.121,95%CI:1.002~1.254;P=0.047)是缺血性脑血管病合并不宁腿综合征的独立危险因素。结论缺血性脑血管病合并不宁腿综合征临床较为常见,此类患者血红蛋白和血清铁水平较低。

Risk factors analysis of ischemic cerebrovascular disease combined with restless legs syndrome

Objective To explore the risk factors for restless legs syndromes (RLS) in patients with ischemic cerebrovascular disease (ICVD).Methods There were 370 patients with ICVD,45 cases were combined with RLS (RLS group) and 325 cases were not combined with RLS (non-RLS group).The general clinical data sex,age,body mass index (BMI),education,nationality,occupation,lifestyle,physical exercise,medical history,history of gestation and age of menopause in female] were recorded,and related chemical examinations white cell count (WBC),hemoglobin (Hb),serum creatinine (Cr),blood urea nitrogen (BUN),fasting blood glucose,serum lipid,plasma homocysteine (Hcy),serum iron] were performed.Results Compared with non-RLS group,BMI of patients in RLS group was higher (t =2.457,P =0.014),Hb (t =2.819,P =0.005) and serum iron (t =2.168,P =0.024) were lower.Multivariate forward Logistic regression analysis showed that low Hb (OR =1.049,95％CI:1.017-1.082;P =0.002) and serum iron (OR =1.121,95％ CI:1.002-1.254;P =0.047) were the risk factors for ICVD combined with RLS patients.Conclusions RLS is common among patients with ICVD,and they have low Hb and serum iron levels.