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齐拉西酮联合文拉法新治疗难治性抑郁症对照研究
引用本文:张勇,于璇.齐拉西酮联合文拉法新治疗难治性抑郁症对照研究[J].河南实用神经疾病杂志,2012(4):22-23.
作者姓名:张勇  于璇
作者单位:[1]郑州市第八人民医院,郑州450006 [2]郑州市金水区总医院,郑州450003
摘    要:目的探讨齐拉西酮联合文拉法新治疗难治性抑郁症的疗效和安全性。方法将84例难治性抑郁症患者随机分为2组,研究组应用齐拉西酮联合文拉法新,对照组单用文拉法新,观察8周。第2、4、8周末采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效,副反应量表(TESS)评定不良反应。结果 2组在第2周末HAMD和HA-MA评分较治疗前均显著下降(P〈0.05),研究组更为明显(P〈0.01)。至第8周末研究组有效率88.10%,对照组66.67%,研究组明显高于对照组(P〈0.05)。不良反应两组间无明显差异(P〉0.05)。结论齐拉西酮联合文拉法新治疗难治性抑郁症,疗效明显优于单一应用文拉法新治疗起效快,不良反应轻,安全性好。

关 键 词:齐拉西酮  文拉法新  难治性抑郁

A control study of ziprasidone combined with venlafaxine in the treatment resistant depression
Zhang Yong,Yu Xuan.A control study of ziprasidone combined with venlafaxine in the treatment resistant depression[J].Henan Journal of Practical Nervous Diseases,2012(4):22-23.
Authors:Zhang Yong  Yu Xuan
Institution:.The Eighth People's Hospital of Zhengzhou,Zhengzhou 450006,China
Abstract:Objective To explore the efficacy and safety of ziprasidone combined with venlafaxine in the treatment of resistant depression. Methods Eighty-four patients with treatment resistant depression were randomly assigned into two groups,research group received ziprasidone combined with venlafaxine and control group received venlafaxine only for 8 weeks.Clinical efficacies were evaluated by the Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA),and adverse reactions were assessed by the treatment emergent symptom scale(TESS) before treatment and at the ends of 2nd,4th,and 8th week treatment. Results At the end of 2nd week,the HAMD scores as well as HAMA scores in both groups decreased obviously than before treatment(P0.05),and more obvious in the research group(P0.01).The effective rate was 88.10% in the research group and 66.67% in the control group,the former was significantly higher than the latter(P0.05).The adverse reactions in both two groups were not significantly different(P0.05). Conclusion Ziprasidone combined with venlafaxine have better efficacy compared to single-use of venlafaxine in the treatment resistant depression,with rapid effect,mild adverse reactions and higher safety.
Keywords:Ziprasidone  Venlafaxine  Treatment resistant depression
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