叶酸在高同型半胱氨酸血症脑梗死患者中的应用

目的观察服用不同剂量叶酸联合维生素B6、维生素B12治疗对急性脑梗死患者血浆同型半胱氨酸的影响。方法伴高同型半胱氨酸血症急性脑梗死患者60例，随机分为A、B2组，每组30例，各给予不同剂量的叶酸，A组2．5mg，1次／d，B组5．0mg，1次／d。2组均同时联合服用维生素战10mg，1次／d；维生素B12 0．5mg，1次／d。分别于治疗前（人院48h内）、治疗15d后采血检测Hcy浓度。结果（1）各组血浆Hcy浓度与治疗前比较均明显降低，差异有统计学意义（P〈0．01）。（2）不同剂量叶酸治疗后血浆Hcy浓度变化差异无统计学意义（P〉0．05）。结论叶酸治疗急性脑梗死伴高Hcy血症有明显效果；应用叶酸2．5mg即可明显降低Hcy。

Effects of of folic acid on the plasma homocysteine level in patients with cerebral infarction

Objective To observe the effects of different dose of folic acid combined of the Vitamin B6 and B12 on homocys- teine level in acute cerebral infarction patients. Methods Sixty acute cerebral infarction patients with hyperhomocysteine were randomly divided into group A and group B, 30 eases in each group. Patients in group A were treated with folio acid 2.5 mg/ d. In group B, the dose was 5.0 mg/d. Two groups were treated with Vitamin B12 10 mg/d and Vitamin B12 0. 5 mg/d as the sametime. The plasma level of homocysteine was measured before and 15 days after treatment in the two groups. Results The plasma level of homoeysteine obviously decreased in the two groups, there was a significant difference （P〈0.01）. The change of homocysteine level has no significant difference between the two groups （P〈0.05）. Conclusion Folio acid is effective intreating acute cerebral infarction patients with hyperhomocysteine. 2.5 mg folic acid is enough to lower homocysteine level obviously.