微信干预对社区精神分裂症患者服药依从性、精神病性症状及复发率影响的Meta分析

目的系统评价微信干预对社区精神分裂症患者服药依从性、精神病性症状及复发率的影响。方法计算机检索PubMed、Cochrane Library、CBM、中国知网、万方和维普数据库,搜集有关微信干预对社区精神分裂症患者影响的随机对照研究,检索时限均为2011年1月1日-2020年11月1日。由2名研究者独立筛选文献、提取数据并评价纳入研究的偏倚风险后,采用Stata 12.0进行Meta分析。结果共检索到381篇文献,最终纳入10项随机对照研究,共1251例患者,其中微信干预组641例,常规健康教育组610例。Meta分析结果显示,相对于常规健康教育组,微信干预组服药依从性(OR=3.05,95%CI:1.98~4.69,P<0.01)更高,PANSS评分(SMD=-1.05,95%CI:-1.46~-0.64,P<0.01)和复发率(OR=0.34,95%CI:0.24~0.48,P<0.01)更低。结论基于微信平台的互动干预方式可能有助于提高社区精神分裂症患者服药依从性、改善精神病性症状和降低复发率。

Effect of WeChat intervention on medication compliance,psychotic symptoms and recurrence rate of schizophrenic patients in community:a Meta-analysis

Objective To systematically review the efficacy of intervention by WeChat on medication compliance,psychotic symptom and recurrence rate of schizophrenic patients in community.Methods Databases including PubMed,the Cochrane Library,CBM,CNKI,Wanfang Data and VIP were searched electronically from January 1,2011 to November 1,2020 to collect randomized controlled trials(RCTs)about the effects of WeChat intervention on community schizophrenic patients.After two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies,the meta-analysis was performed with Stata 12.0 software.Results A total of 381 articles were retrieved and finally 10 RCTs were included,including 1251 patients with WeChat intervention group 641 cases and routine health education group 610 cases.Meta-analysis showed that compared with the conventional health education group,the WeChat intervention group had higher medication compliance(OR=3.05,95%CI:1.98~4.69,P<0.01),lower PANSS score(SMD=-1.05,95%CI:-1.46~-0.64,P<0.01)and relapse rate(OR=0.34,95%CI:0.24~0.48,P<0.01).Conclusion The interactive intervention based on WeChat platform can effectively improve the medication compliance of patients with schizophrenia in the community,help to reduce the severity of psychotic symptoms and the recurrence rate.