艾司西酞普兰联合心理治疗对首次抑郁发作的影响

目的探讨艾司西酞普兰联合心理治疗对首次抑郁发作的临床疗效。方法选取在山东省精神卫生中心门诊治疗的符合《国际疾病分类(第10版)》(ICD-10)中的首次抑郁发作诊断标准的患者120例,随机分为研究组和对照组各60例,研究组给予艾司西酞普兰联合心理治疗,对照组给予艾司西酞普兰治疗。共观察24周。于治疗前、治疗后第2、8、24周末采用汉密尔顿抑郁量表(HRSD)进行评定,比较治疗后24周末两组总有效率;并于2年后电话随访,比较两组复发率。结果治疗2、8周末HRSD评分研究组均低于同时点对照组(21.03±4.89)分vs.(25.57±4.37)分,(9.60±4.22)分vs.(21.52±2.72)分,P0.05或0.01];24周末研究组痊愈率与对照组比较差异无统计学意义(60.0%vs.56.7%,χ2=0.14,P0.05);2年末电话随访研究组复发率低于对照组(31.7%vs.61.7%,χ2=10.85,P0.01)。结论艾司西酞普兰联合心理治疗对首次抑郁发作疗效优于单纯艾司西酞普兰治疗,复发率低。

Effects of escitalopram combined with psychological therapy on the first episode depression

Objective To investigate the Effects of escitalopram combined with psychological therapy on the first episode depres-sion. Methods 120 patients were divided into the study group（60,psychological therapy combined with escitalopram）and control group （60,escitalopram therapy）. All patients were assessed with Hamilton Rating Scale for Depression（HRSD）at the baseline and at the end of the 2nd ,8th ,24th week of the treatment to evaluate the efficacy. Compared recurrence rate of the two groups by telephone in the follow-up 2 years. Results Treatment of 2th ,8th week study group scores were lower than the control group at the same time（21. 03 ± 4. 89） vs.（25. 57 ± 4. 37）（,9. 60 ± 4. 22）vs.（21. 52 ± 2. 72）,P﹤0. 05 or 0. 01]. 24th week study groupˊs cure rate and control groupˊs quite （60. 0% vs. 56. 7%,χ^2 =0. 14,P﹥0. 05）;follow-up 2 years study groupˊs recurrence rate significantly lower than control groupˊs （31. 7% vs. 61. 7%,χ^2 =10. 85,P﹤0. 01）. Conclusion Escitalopram combined with psychological treatment on the first depression curative effect is better than escitalopram treatment,and significantly reduced the recurrence rate.