Unmasking antibiotic-associated neurological disorders: The underminer in Intensive Care Unit |
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| Institution: | 1. Edmon J. Safra Program in Parkinson''s Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada;2. Centro de Memoria, Instituto de Neurociencias de la Fundación Favaloro, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina;3. Departamento de Ciencias Sociales, Universidad de San Andrés, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina;1. Community Brain Injury Service, Morriston Hospital, Swansea, United Kingdom;2. Health and Wellbeing Academy, Swansea University, Swansea, United Kingdom;3. Fieldbay, Swansea, United Kingdom;4. Department of Psychology, Swansea University, Swansea, United Kingdom;5. Norwich Medical School, University of East Anglia, Norwich, United Kingdom;1. Harvard South Shore Residency Training Program, Brockton, MA, United States;2. VA Boston Healthcare System, Brockton Division, 940 Belmont Avenue, Brockton, MA, United States;3. Department of Psychiatry, Harvard Medical School, Brockton Campus, MA, United States |
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| Abstract: | Psychosis is a common and intractable disorder of hospitalization, especially in patients hospitalized in Intensive Care Unit (ICU). Along with the widely use of multiple antibiotics in community-acquired infection and hospital-acquired infection, the occurrence of antibiotic-associated neurological disorders has become more frequently. However, antibiotic neurotoxicity is often overlooked or misinterpreted. In this review, we summarized the neurological disorders caused by antibacterial agent usage and firstly systematically formulated the pathogenesis of antibiotic-associated neurotoxic reactions. Precautions of the complications are critical in preventing serious clinical outcome as the inducement is curable. Regular neurological physical examination, electroencephalogram (EEG) examination, lumbar puncture and therapeutic drug monitoring closely are essential for early diagnosis and differential diagnosis. |
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| Keywords: | Antibiotic-associated encephalopathy Aseptic meningitis Mental disorders γ-Aminobutyric acid |
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