癫癎撤药的研究进展

癫癎并非完全是一种终身疾病,60%~70%患者经过一定时间抗癫癎药(AEDs)治疗后症状能得到缓解(至少5年不发作),缓解后及时合理地AEDs撤药将对患者的预后包括避免或减少药物不良反应以及改善生活质量等产生重要影响。对AEDs撤药的研究已有60年历史,然而目前仅依据临床经验撤药,缺乏循证医学依据。对达到撤药的要求、时机及具体方法亦无统一被认可的标准。本文就AEDs撤药对癫癎复发的影响,撤药时机、速度,撤药后复发的危险因素等方面的研究进行综述。

Research Progression of Anti-epileptic Drug Withdrawal

Epilepsy is not completely a lifelong disease,60%-70% patients’symptoms can be relieved（no attack for at least 5 years） after a certain period of anti-epileptic drugs（AEDs） treatment.A proper and timely withdrawal will have an significant impact on patients’prognosis,such as avoiding or alleviating side effects,improving quality of life,and so on.Although it has been 60 years since researchers began the study of drug withdrawal,physicians still make decisions on withdrawal through clinical experience rather than the evidencebased medicine.What’s more,there are no unified standards about the time,requirements,or specific methods.This article gave a review of the effects of withdrawal on relapse,the risk factors of relapse after drug withdrawal,when and how to withdraw AEDs,and so on.