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| 磁共振弥散张量成像对阿尔茨海默病脑白质损害的评估及鉴别价值 | |
| 引用本文： | 付剑亮,常诚,李文彬,赵玉武.磁共振弥散张量成像对阿尔茨海默病脑白质损害的评估及鉴别价值[J].中国临床神经科学,2010,18(5):456-462. |
| 作者姓名： | 付剑亮 常诚 李文彬 赵玉武 |
| 作者单位： | 1. 上海交通大学附属第六人民医院神经内科,200233 2. 上海交通大学附属胸科医院核医学科,200030 3. 上海交通大学附属第六人民医院放射科,200233 |
| 基金项目： | 上海市卫生局资助项目，上海交通大学"医工(理)交叉研究基金"项目，上海市科学技术委员会重大科技支撑计划科研项目 |
| 摘 要： | 目的：应用MR弥散张量成像（DTI）观察阿尔茨海默病（AD）患者脑白质纤维束完整性。方法：健康老年志愿者为对照组（NC）组、遗忘型轻度认知障碍（aMCI）组、AD组和皮质下缺血性血管性痴呆（SIVD）组各20例,行常规MRI和DTI扫描后,测定相同感兴趣区（ROI）的各向异性分数（FA）值和表观扩散系数（ADC）值进行比较。结果：与NC组比较, AD组前额叶、颞叶、海马等部位FA值降低,颞叶、海马等部位ADC值升高（P〈0.05）;aMCI组仅扣带束FA值降低,与AD组比差异有统计学意义（P〈0.05）;SIVD组下额枕束等部位FA值下降,ADC值升高,与AD组比较差异有统计学意义（P〈0.05）。结论：DTI可以用来评估白质纤维束完整性,AD组白质损害甚于aMCI患者;扣带束FA值可以作为aMCI患者筛查的指标;根据受累部位不同可对SIVD与AD进行鉴别。 |
| 关 键 词： | 阿尔茨海默病 轻度认知功能障碍 血管性痴呆 弥散张量成像 |
The Value of Diffusion Tensor Imaging in Evaluating the Changes of Microstructural Integrity of White Matter in Alzheimer's Disease Patients |
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| FU Jian-Liang,CHANG Cheng,LI Wen-Bin,ZHAO Yu-Wu.The Value of Diffusion Tensor Imaging in Evaluating the Changes of Microstructural Integrity of White Matter in Alzheimer's Disease Patients[J].Chinese Journal of Clinical Neurosciences,2010,18(5):456-462. | |
| Authors: | FU Jian-Liang CHANG Cheng LI Wen-Bin ZHAO Yu-Wu |
| Institution: | FU Jian-Liang~1,CHANG Cheng~2,LI Wen-Bin~3,ZHAO Yu-Wu~1 1 Department of Neurology,the Sixth People' s Hospital,Shanghai Jiaotong University,Shanghai 200233,2 Department of Nuclear Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,3 Department of Radiology,the Sixth People's Hospital,China |
| Abstract: | Aim:To study the integrity of white matter(WM) fiber tracts in patients with Alzheimer's disease (AD)(P<0.05) using diffusion tensor imaging(DTI).Methods:Four groups were identified and compared. They are normal control(NC) group,amnestic mild cognitive impairment(aMCI) group,AD group and subcortical ischemic vascular dementia(SIVD) group,20 cases in each group.After routine MRI and DTI were completed,fractional anisotropy(FA) and apparent diffusion coefficient(ADC) values were measured and compared on regi... |
| Keywords: | Alzheimer's disease mild cognitive impairment vascular dementia diffusion tensor imaging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |