| 雌激素对癫痫持续状态大鼠海马CA3区神经元保护作用的研究 |
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| 引用本文： | 谭兰,刘震.雌激素对癫痫持续状态大鼠海马CA3区神经元保护作用的研究[J].中国临床神经科学,2003,11(3):258-262. |
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| 作者姓名： | 谭兰 刘震 |
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| 作者单位： | 1. 青岛大学医学院附属医院神经内科,266003
2. 山东大学第二医院神经内科,250012 |
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| 摘 要： | 目的研究雌激素对癫癎持续状态大鼠海马CA3区神经元保护作用.方法利用尼氏染色和免疫组化染色技术,观察癫癎发作前后给予雌激素治疗对癫癎发作造成神经元凋亡及Bcl-2、Bax表达的影响.结果癫癎发作前给予雌激素治疗可明显减轻持续癫癎发作造成的神经元缺失并可抑制Bax表达,但对Bcl-2表达无明显影响.结论雌激素对癫癎持续状态导致的海马神经元损伤有保护作用,对凋亡促进基因Bax表达的影响可能参预了其神经保护作用.
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| 关 键 词： | 雌激素 癫癎持续状态 神经保护作用 Bcl-2 Bax |
| 文章编号： | 1008-0678(2003)03-0258-05 |
| 修稿时间： | 2002年10月22 |
The Neuroprotective Effects of Estrogens on Status Epileptics-induced Hippocampal Cell Damage |
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| Abstract: | Aim:To examine the neuroprotective effects of estrogens on status epileptics-induced hippocampal cell damage. Methods:Neuronal damage was evaluated in Nissl-stained sections. Immunohistochemistry technique was used to investigate the expression of the cell death regulatory genes Bcl-2 and Bax. Results: Estrogens pretreatment, as well as the combination of pretreatment and posttreatment, showed less damaged in the hippocampal CA3 subfield and inhibited the expression of the Bax induced by seizures, but the expression of the Bcl-2 was not affected.Conclusion:Our results suggest that estrogens can be beneficial in protecting against status epilepticus-induced hippocampal damage. The inhibition to the expression of Bax may be involved the neuroprotective effects of estronges. |
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| Keywords: | estrogens status epileptics neuroprotective effects Bcl-2 Bax |
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