不安腿综合征的主观睡眠质量评估及多导睡眠图研究

目的了解不安腿综合征(RLS)患者的主、客观睡眠质量,以及RLS严重程度量表评分与睡眠质量的相关性。方法选取30例RLS患者(RLS组)和30名年龄、性别匹配的健康正常人(对照组),通过BECK抑郁量表、BECK焦虑量表、Chalder疲惫量表、匹兹堡睡眠质量指数量表、Epworth嗜睡量表、RLS生活质量量表评估RLS患者主观睡眠质量及生活质量。运用多导睡眠图分析患者客观睡眠质量情况。对RLS严重程度与睡眠质量进行相关性分析。结果与对照组比较,RLS组抑郁量表评分、Chalder疲惫量表评分、匹兹堡睡眠质量指数量表评分均增高。RLS严重程度量表评分(IRLS)与Chalder疲惫量表评分、匹兹堡睡眠质量指数量表评分及RLS生活质量量表评分具有显著相关性。多导睡眠图检测:RLS组总睡眠时间减少,睡眠效率下降;N1期睡眠比例、入睡后清醒时间及微觉醒指数增高;RLS组睡眠期周期性肢体运动(PLMS)指数显著增高(P0.001)。IRLS评分与PLMS指数具有相关性(r=0.371,P=0.044),而与其他客观睡眠参数无相关性。结论 RLS显著影响患者睡眠质量及生活质量,且主观睡眠质量、生活质量及PLMS指数与IRLS具有相关性。

Subjective Sleep and Awakening Quality and Polysomnographic Studies in Patients with Restless Legs Syndrome

Aim To investigate the objective and subjective sleep and awakening quality in restless legs syndrome （RLS）,and test the correlation between RLS severity （international restless legs syndrome rating,IRLS） and sleep laboratory measurements.Methods 30 RLS patients free ofpsychotropic drugs were studied as compared with age-and sex-matched normal controls,utilizing clinical evaluations by the BECK Depression Inventory （BDI） and BECK Anxiety Inventory （BAI）,Chalder Fatigue Scale-14 （FS-14）,RLS-Quality of life （RLSQoL）,the Pittsburgh Sleep Quality Index （PSQI）,and the Epworth Sleepiness Scale to investigate the subjective sleep and awakening quality.Objective sleep and awakening quality were evaluated by utilizing polysomnography （PSG） in the sleep laboratory.Results Scores of the PSQI,BDI,and FS-14 were found increased in RLS patient groups; RLS severity （IRLS） was correlated significantly with PSQI,FS-14 and RLSQoL.RLS patients exhibited shorter total sleep time,lower sleep efficiency,higher arousal index.During the sleep period,the percentage of wake and sleep stage 1 increased in RLS patients.The PLMS index markedly increased in RLS group.IRLS was correlated significantly with PLMS index.There was no correlation between IRLS and any other sleep variable during PSG.Conclusion RLS negatively affects objective and subjective sleep and awakening quality.There was a correlation between IRLS and subjective sleep quality and objective parameters of motor dysfunction such as PLMS-index.