| NADPH氧化酶p22phox亚基基因多态性在动脉粥样硬化性脑梗死发病中的意义 |
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| 引用本文： | 冯玉兰,孙家兰,严志敏,芦钟娇,倪培华,傅毅.NADPH氧化酶p22phox亚基基因多态性在动脉粥样硬化性脑梗死发病中的意义[J].中国临床神经科学,2013(6):649-654. |
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| 作者姓名： | 冯玉兰 孙家兰 严志敏 芦钟娇 倪培华 傅毅 |
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| 作者单位： | [1]上海市闵行区中心医院神经内科,上海201100 [2]上海市公利医院神经内科,上海200135 [3]上海交通大学医学院附属瑞金医院神经内科 ,上海200135 [4]上海交通大学医学院附属瑞金医院检验系,上海200025 |
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| 基金项目： | 上海市闵行区自然科学研究课题（编号：2012MHz046） |
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| 摘 要： | 目的探讨还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶p22phox亚基-A930G、C549T基因多态性与动脉粥样硬化性脑梗死（cI）的关系。方法采用PCR-RFLP技术检测269例CI患者（cI组）和187例无CI对照者（对照组）的基因多态性。结果与对照组比较，cI组的一A930G基因型分布差异有统计学意义，而．A930G等位基因、C549T基因型和等位基因分布差异无统计学意义。另外，等位基因930A与549T配对、呈单倍型AT时，cI组的出现率明显高于对照组。结论-A930G的基因突变可能与急性cI的发生相关，同时单倍型AT可能使cI的发病风险增高。
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| 关 键 词： | 还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶 -A930G C549T 基因多态性 脑梗死 |
Significance of the Nicotinamide Adenine Dinueleotide Phosphate Oxidase Subunit p22phoxPolymorphism in Atherosclerotic Cerebral Infarction |
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| FENG Yu-lan^l,SUN Jia-lan^,YAN Zhi-min^l,LU Zhon-jiao^,NI Pei-hua^,FU Yi.Significance of the Nicotinamide Adenine Dinueleotide Phosphate Oxidase Subunit p22phoxPolymorphism in Atherosclerotic Cerebral Infarction[J].Chinese Journal of Clinical Neurosciences,2013(6):649-654. |
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| Authors: | FENG Yu-lan^l SUN Jia-lan^ YAN Zhi-min^l LU Zhon-jiao^ NI Pei-hua^ FU Yi |
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| Institution: | 1Department of Neurology, Minhang District Central Hospital, Shanghai 201100; 2Department of Neurology, Shanghai Gongli Hospital, Shanghai 200135; 3Department of Neurology, 4Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China |
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| Abstract: | Aim To evaluate the association between the polymorphisms of the NADPH oxidase subunit p22phox gene -A930G, C549T and atherosclerotic cerebral infarction （CI） risk. Methods The genotypes of the -A930G, C549T were detected by the polymerase chain reaction-restriction fragment length polymorphism in 269 CI patients and 187 subjects without CI. Results Compared with the subjects without CI, there was significant statistic association among the -A930G genotype mutations, and there were no significant statistic differences in the distribution of-A930G alleles, C549T genotypes and alleles. The frequency of AT haplotype was significantly higher than that in the CI group. Conclusion -A930G gene mutations might be susceptible individually to the risk of CI, while AT haplotype carrier demonstrating a higher risk of CI. |
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| Keywords: | nicotinamide adenine dinucleotide phosphate oxidase -A930G C549T genepolymorphism cerebral infarction |
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