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SORL1基因多态与阿尔茨海默病发病风险的Meta分析
引用本文:于会艳,秦斌,周海滨. SORL1基因多态与阿尔茨海默病发病风险的Meta分析[J]. 中华神经医学杂志, 2008, 7(12)
作者姓名:于会艳  秦斌  周海滨
作者单位:1. 卫生部北京医院神经内科,北京,100730
2. 山东大学医学院医学遗传学研究所,济南,250012
摘    要:目的 运用Meta分析的方法探讨SORL1基因rs2070045位点基因多态与阿尔茨海默病(AD)发病风险的关系.方法 应用SORL1、sortilin-related recepmr、Alzheimer等关键词,检索Medline、Cochrane网书馆和中国生物医学文献数据库(CBM)发表的文章并附以文献追溯方法.应用RevMan4.2软件进行统计分析.结果 三篇文献共11组不同种族人群纳入分析,共有AD组2927例.对照组3869例.AD组和对照组rs2070045位点基因多态现象巾GG+GT基因型频率与最常见的纯合子TT基因型频率比的合并比值比(OR)值为1.19,95%可信区间为1.08~1.31,Z=3.39,P=0.0007,等位基因频率合并OR值为1.17,95%可信区间为1.07~1.27,Z=3.67,P=0.0002.结论 SORL1基因rs2070045位点多态性与AD患病风险相关.

关 键 词:阿尔茨海默病  SORL1基因  多态性  Meta分析

Meta-analysis of the relation between the SORLI gene polymorphism and the onset risk of AIzheimer's disease
YU Hui-yan,QIN Bin,ZHOU Hai-bin. Meta-analysis of the relation between the SORLI gene polymorphism and the onset risk of AIzheimer's disease[J]. Chinese Journal of Neuromedicine, 2008, 7(12)
Authors:YU Hui-yan  QIN Bin  ZHOU Hai-bin
Abstract:Objective To investigate the relation between the rs2070045 locus polymorphism in the SORL1 gene and the onset risk of AD by means of Metβ-analysis. Methods Databases (Medline, Cochrane Library and CBM) were searched using keywords like SORL1, sortilin-related receptor, Alzheimer and so on, and a manual search of citations was also performed from relevant original studies and literatures. All analyses were conducted with Review Manager Version4.2 software. Results 3 literatures with 11 different ethnic groups were studied, totally including the AD group (2927 cases) and the control (3867 cases). The summary OR for studies with frequency of GG+GT genotype at rs2070045 locus in the SORLI gene was 1.19 (95%CI: 1.08-1.31, Z=3.39, P=0.0007), when it compared with the common homozygote ofTT genotype. The summary OR for allele frequency was 1.17 (95%CI: 1.07-1.27, Z=3.67, P=0.0002). Conclusion The metβ-analysis suggests that the polymorphism at rs2070045 locus of SORL1 gene might be a genetic risky factor for AD.
Keywords:Alzheimer's disease  SORL1 gene  Polymorphism  Metβ-analysis
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