| TRPV1受体与认知障碍相关性的研究进展 |
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| 引用本文： | 袁洁,苏凯奇,李瑞青,刘环环,冯慧利,黄娣,冯晓东.TRPV1受体与认知障碍相关性的研究进展[J].中华神经医学杂志,2021(3):308-312. |
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| 作者姓名： | 袁洁 苏凯奇 李瑞青 刘环环 冯慧利 黄娣 冯晓东 |
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| 作者单位： | 河南中医药大学康复医学院;河南中医药大学第一附属医院康复中心 |
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| 基金项目： | 国家自然科学基金联合基金项目(U2004131);国家自然科学基金(81574042);河南省中医管理局国家中医临床研究基地科研专项(2018JDZX011)。 |
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| 摘 要： | 瞬时受体电位香草酸亚型1(TRPV1)受体与外周神经系统疾病的相关性已经得到证实,而近年来越来越多研究也证实TRPV1在中枢神经系统中的重要地位,其在海马区、皮层及中脑的广泛分布更是为TRPV1受体与认知学习记忆功能的相关性架起了桥梁。本文通过综述国内外TRPV1受体在中枢神经系统中的生物学作用,总结其与认知相关疾病的关系,旨在为TRPV1受体是否可作为治疗认知相关疾病的药物靶点提供理论依据。
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| 关 键 词： | 瞬时受体电位香草酸亚型1 认知障碍 阿尔茨海默病 帕金森病 脑卒中 |
Recent advance in relation between transient receptor potential vanilloid-1 receptor and cognitive dysfunction |
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| Yuan Jie,Su Kaiqi,Li Ruiqing,Liu Huanhuan,Feng Huili,Huang Di,Feng Xiaodong.Recent advance in relation between transient receptor potential vanilloid-1 receptor and cognitive dysfunction[J].Chinese Journal of Neuromedicine,2021(3):308-312. |
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| Authors: | Yuan Jie Su Kaiqi Li Ruiqing Liu Huanhuan Feng Huili Huang Di Feng Xiaodong |
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| Institution: | (School of Rehabilitation Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Rehabilitation Center,First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China) |
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| Abstract: | The correlation between transient receptor potential vanilloid-1(TRPV1)receptor and peripheral nervous system diseases has been confirmed.In recent years,studies have shown that TRPV1 plays an important role in the central nervous system;its wide distribution in the hippocampus,cortex,and midbrain bridges the correlation between TRPV1 receptor and cognitive learning and memorial function.This paper reviews the biological role of TRPV1 receptor in the nervous system at home and abroad and concludes the relations of TRPV1 receptor with cognitive associated diseases,aiming at providing theory basis for whether TRPV1 receptors can be used as therapeutic drug targets for cognitive associated diseases. |
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| Keywords: | Transient receptor potential vanilloid-1 Cognitive dysfunction Alzheimer's disease Parkinson's disease Stroke |
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