Institution: | aDepartment of Psychiatry, Huai’an No.3 Hospital, Huai’an, Jiangsu Province, China bDepartment of Psychiatry, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China cDepartment of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu Province, China dDepartment of Psychiatry, Yangzhou Wutaishan Hospital, Yangzhou, Jiangsu Province, China eDepartment of Psychiatry, Suzhou Puji Hospital, Suzhou, Jiangsu Province, China. |
Abstract: | BACKGROUND: Weight gain and type 2 diabetes mellitus (DM) are often linked to antipsychotics treatment. The aim of the study is to investigate serum free fatty acids (FFA) levels in schizophrenic patients who received long-term antipsychotics treatment, and to explore the associations between serum FFA and fasting blood glucose, and insulin resistance. METHODS: 308 inpatients with schizophrenia who met with the criteria of DSM-IV were recruited into this study, and were divided into four groups: control subjects, single obesity, impaired glucose tolerance (IGT) and type 2 DM according to different body mass index, fasting blood glucose level and 2-hour postprandial blood glucose. Serum FFA was measured with colorimetry. Serum insulin and leptin were measured with radioimmunoassay respectively. RESULTS: There was a significant elevation in serum FFA levels in schizophrenic patients who received long-term antipsychotics treatment, especially in single obesity, IGT, and DM groups. The elevated serum FFA was remarkably positive correlated with fasting blood glucose and insulin resistance. CONCLUSIONS: The study suggested the elevated serum FFA in schizophrenic patients with long-term antipsychotics treatment affected the blood glucose metabolism, may have played an important role in insulin resistance and type 2 DM, and was also an important trait of metabolic syndromes. |