High-Dose Phenytoin in the Treatment of Refractory Epilepsy |
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Authors: | Jorge Eslava Cobos |
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Institution: | Clinica de Epilepsia, Instituto Neurologico de Colombia, Bogota, Colombia |
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Abstract: | Refractory, long-standing, high-frequency epilepsy was successfully managed with high-dose phenytoin treatment. Side effects were observed in only three patients and were easily corrected. Most of the patients had partial seizures, but many also had a myoclonic component. Emphasis was placed on monotherapy whenever possible. Results, interpretation of serum levels, and toxic reactions to phenytoin are discussed. |
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Keywords: | Refractory epilepsy Phenytoin Serum levels Toxicity |
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