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Spread of Epileptic Seizure Activity in Humans |
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| Authors: | Nicolaas J I Mars Paul M Thompson Robert J Wilkus† |
| Institution: | Medical Informatics, University of Leiden, The Netherlands;*Regional Epilepsy Center and Department of Neurological Surgery, Harborview Medical Center;†Division of Electroencephalography and Clinical Neurophysiology, Department of Laboratory Medicine, and Division of Neurology, Department of Medicine, University of Washington, Seattle, Washington, U.S.A. |
| Abstract: | A computer-augmented approach to ictal EEG analysis has been developed. A method for determining both the predictability of one signal from another and the time delay between those two signals--the average amount of mutual information (AAMI) method--has been applied to representative seizures of two patients with focal-onset seizures and one patient with generalized seizures. High AAMI values characterized the EEG derived from the sites of the epileptic foci. AAMI values were high in all sampled brain areas in the patient with generalized seizures. Time delays were not consistent in any subject. The results indicate that the AAMI technique can differentiate focal from generalized seizures and identify the site of seizure onset. |
| Keywords: | Epilepsy Focus location Mutual information Seizure analysis Time delays |