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Temporal Lobectomy in Early Childhood
Authors:Michael Duchowny‡  Bonnie Levin‡§  Prasanna Jayakar  Trevor Resnick‡  Luis Alvarez‡  Glenn Morrison†  Patricia Dean
Institution:Department of Neurology, Miami Children's Hospital, Florida 33155.
Abstract:Children with medically resistant temporal lobe seizures that persist into adolescence often experience psychosocial deterioration and medical morbidity. It is therefore especially important to evaluate the contribution of surgical therapy in preadolescent children. We describe our experience with temporal lobectomy in 16 children less than 12 years (mean age 7 years) who had intractable seizures of temporal lobe origin. Structural lesions were identified on neuroimaging studies in 11 patients. In all patients, the standard anterior temporal lobectomy was tailored according to the extent of the lesion and epileptogenic field. At follow-up, 11 children were seizure-free, three were 90% improved, one was 50% improved, and one was unchanged. Neuropathological abnormalities were identified in virtually all children. Prenatally acquired abnormalities of neurogenesis were the most common, whereas mesial temporal sclerosis was found in only two children. We conclude that tailored temporal lobectomy in the first decade of life is highly beneficial in carefully selected children with medically refractory seizures.
Keywords:Epilepsy  Neurosurgery  Temporal lobe  Child
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