Is regulation of body weight elucidated?

A new perspective on mechanisms involved in the regulation of a constant fat body mass and its relation to body energy balance is presented on the basis of a series of experiments. A study of the neuroendocrine conditions underlying the daily weight gain-weight loss cycle in rat and man and experimentally induced over and underweight, leads to the notion that lipogenesis and lipolysis above and below a range of physiological fluctuations of body fat develop a counter-regulatory tendency to correcting lipolysis and lipogenesis respectively. This development is attributed to a chronic central action of plasma insulin concentration on hypothalamic insulin receptors. This liporegulatory system which controls and regulates the filling and emptying of fat stores modulates the feeding system which controls and regulates the filling of a gastrointestinal store by eating and its emptying by metabolic food utilization.