Molecular theory of obesity, sterility and other behavioral and endocrine problems in genetically obese mice (ob/ob) |
| |
Authors: | David L Margules |
| |
Institution: | Department of Psychology, Temple University, Philadelphia, PA l9l22, USA |
| |
Abstract: | A translation defect in the messenger RNA that translates the glycosylated protein pro-opiocortin may account for many of the endocrine and behavioral problems in the C57BL/6J ob/ob genetically obese mouse. This is the first proposal of a mechanism for the generation, by a single gene, of the complete set of abnormal behaviors and endocrine disturbances in the obese mouse. |
| |
Keywords: | Obesity Sterility Behavior Endocrine problems Mice Pro-opiocortin Big ACTH |
本文献已被 ScienceDirect 等数据库收录! |
|