Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines |
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Authors: | Sinkkonen S T Mihalek R M Homanics G E Lüddens H Korpi E R |
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Institution: | Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland. |
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Abstract: | We searched for subunit correlations for GABA(A) receptor-associated atypically GABA-insensitive 35S]TBPS binding. The homomeric beta3 subunit receptors could be excluded, as GABA-insensitive 35S]TBPS binding was present in beta3-/- mice. Localization of GABA-insensitive 35S]TBPS binding correlated best with those of delta, alpha4 and alpha6 subunit mRNAs. The amounts of GABA-insensitive 35S]TBPS binding components were increased in delta-/- mice, but dramatically reduced in alpha6-/- mice, suggesting a role for alpha6 but excluding delta subunits. |
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