Cerebral activation patterns in patients with writer's cramp: a functional magnetic resonance imaging study |
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Authors: | Christine Preibisch Daniela Berg Erich Hofmann Laszlo Solymosi Markus Naumann |
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Institution: | Bayerische Julius-Maximilians-Universit?t, Josef-Schneider-Stra?e 11, 97080 Würzburg,Germany, Tel.: +49-931-2012621, Fax: +49-9367-980388, e-mail: naumann@mail.uni-wuerzburg.de, DE
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Abstract: | Functional MRI (fMRI), visualizing changes in cerebral blood oxygenation, has to date not been performed either in patients
with writer's cramp or in healthy subjects during writing. We compared the cerebral and cerebellar activation pattern of 12
patients with writer's cramp during writing with a group of 10 healthy subjects performing the same tasks over 30-s periods
of rest or writing. Sixty echo planar imaging multi-slice datasets were analysed using SPM96 software. Data were analysed
for each subject individually and groupwise for patients vs. controls. Healthy subjects showed a significant activation of
the ipsilateral dentate nucleus, contralateral cerebellar hemisphere, contralateral primary sensorimotor cortex, and contralateral
precentral gyrus during writing. Patients with writer's cramp showed significantly greater activation of the ipsilateral cerebellar
hemisphere than controls. Also the activation in the primary sensorimotor cortex extended further caudally and anteriorly
towards the premotor association area. Activation was observed in the thalamus during writing only among the patients. Our
results indicate an increased basal ganglia output via the thalamus to the motor and premotor cortical areas in dystonia patients
and support the notion of disinhibition of the motor cortex leading to coconcentrations and dystonic postures.
Received: 10 November 1999 / Received in revised form: 4 April 2000 / Accepted: 26 April 2000 |
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Keywords: | Functional magnetic resonance imaging Writer's cramp Cerebral and cerebellar activation pattern |
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