Lymphocyte stimulation by acetylcholine receptor in polymyositis |
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| Authors: | B M Conti-Tronconi M Morgutti M G Albizzati F Clementi |
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| Institution: | (1) Departments of Pharmacology and Neurology of the University of Milan, Italy;(2) CNR Center of Cytopharmacology, 20129 Milano, Italy |
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| Abstract: | Summary Lymphocytes of twenty-seven patients with polymyositis were incubated in vitro with cholinergic receptor rich membranes obtained from the electric organs of Torpedo Marmorata.Lymphocytes of polymyositic patients were slightly stimulated; positive responses were present mainly in patients affected from more than a year. Sensitization against the nicotinic cholinergic receptor may explain the occurrence of the myasthenic syndrome with polymyositis.Fellow of the  A. Villa Rusconi foundation |
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| Keywords: | Polymyositis Myasthenia gravis Acetylcholine receptor Lymphocyte stimulation |
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