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抑郁症患者识别负性表情的脑磁源性影像动态变化
引用本文:韩颖琳,姚志剑,江海腾,卢青,张婧,滕皋军.抑郁症患者识别负性表情的脑磁源性影像动态变化[J].中华精神科杂志,2010,43(3).
作者姓名:韩颖琳  姚志剑  江海腾  卢青  张婧  滕皋军
作者单位:1. 南京医科大学脑科医院精神科,210029
2. 东南大学学习科学研究中心
3. 东南大学临床医学院
基金项目:国家高技术研究发展计划(863计划)资助项目,国家自然科学基金,儿童发展与学习科学教育部重点实验室开发课题 
摘    要:目的 利用磁源性影像技术以及表情事件相关识别实验范式探讨抑郁症患者识别负性动态表情的神经网络磁源性影像动态变化的特点.方法 利用脑磁图检测12例抑郁症患者(患者组)及12名年龄、性别、受教育年限近似匹配的健康对照者(对照组)识别负性动态表情视频时的脑部反应.设P<0.01时,差异均具有统计学意义.结果 与对照组相比,患者组识别负性面部表情时,活动异常主要出现在双侧钩回、双侧颞上回、右额中回、右杏仁核、右颞回下、左梭状回、左枕下回、右海马旁回、左枕舌回、双侧楔前叶、左楔叶等脑区,这些脑区组成的神经网络在识别负性动态表情过程有相应脑区激活异常.结论 抑郁症患者识别负性表情的功能网络的脑磁源性影像动态变化特点与正常人比较差异有统计学意义.

关 键 词:抑郁症  脑磁图描记术  负性情绪识别

The dynamic characteristics of magnetic source imaging of recognizing negative expression in major depressive disorder
Abstract:Objective To explore the features of functional networks about recognizing dynamically negative expression using magnetoencephalography (MEG) and the paradigm of expressional experiment,and to examine its neurological basis. Methods Twelve depressed patients and 12 age- and educationmatched healthy controls participated to recognize the dynamically negative expression during MEG scanning. Results Compared with healthy controls, the abnormally activities regions in depressed patients during different time periods were separately as follow: the bilateral uncus gyrus, bilateral superior temporal gyrus, right middle frontal gyrus, right amygdale, right temporal sub-gyrus, left angular gyrus, left caudate nucleus head, left inferior occipital gyrus, right parahippocampal gyrus, left fusiform gyrus, bilateral precuneus, left anterior lobe culmen, and left cuneus ( P<0.01, uncorrected). Conclusion Abnormal brain activity is distributed extensively in depressed patients during recognizing dynamically negative expression, which may prompt the features of functional networks about recognizing dynamically negative expression.
Keywords:Depression  Magnetoencephalography  Negative emotion recognition
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